由水杨酸和炔酸酯合成官能化苯并[1,3]二氧杂环丁烷-4-酮及其直接酰胺化反应

Bhaskaran Rasmi P, Nayak Kalinga H, Babu Beneesh P

Department of Chemistry, National Institute of Technology Karnataka - NITK Surathkal 575025 Mangalore India

RSC Adv. 2021 Jul 13;11(40):24570-24574. doi: 10.1039/d1ra05032j.

Direct synthesis of 4-benzo[][1,3]dioxin-4-one derivatives from salicylic acids and acetylenic esters (both mono- and disubstituted) has been described. The reaction is mediated by CuI and NaHCO in acetonitrile. Room temperature amidation of the synthesized 1,3-benzodioxinones with primary amines readily afforded the corresponding salicylamides in moderate to good yields.

已报道了由水杨酸和炔酸酯（单取代和双取代）直接合成4-苯并[][1,3]二氧杂环己二酮衍生物的方法。该反应由碘化亚铜和碳酸氢钠在乙腈中介导。合成的1,3-苯并二氧杂环己二酮与伯胺在室温下进行酰胺化反应，很容易以中等至良好的产率得到相应的水杨酰胺。