帚曲喹诺酮B，一种从源自珊瑚的帚霉属真菌中分离出的新型单萜二氢喹啉-2(1H)-酮。

Scopuquinolone B, a new monoterpenoid dihydroquinolin-2(1H)-one isolated from the coral-derived Scopulariopsis sp. fungus.

作者信息

Mou Xiao-Feng, Liu Xin, Xu Ru-Fang, Wei Mei-Yan, Fang Yao-Wei, Shao Chang-Lun

机构信息

a Key Laboratory of Marine Drugs, School of Medicine and Pharmacy , Ocean University of China , Qingdao , The People's Republic of China.

b Technical Center, Beijing Entry-Exit Inspection and Quarantine Bureau , Beijing , The People's Republic of China.

出版信息

Nat Prod Res. 2018 Apr;32(7):773-776. doi: 10.1080/14786419.2017.1359177. Epub 2017 Aug 8.

DOI:10.1080/14786419.2017.1359177

PMID:28783962

Abstract

Further chemical investigation of the secondary metabolites of the fungus Scopulariopsis sp. led to the discovery of a new alkaloid, scopuquinolone B (1). The structure of compound 1 was elucidated by extensive NMR spectroscopic data, CD spectrum and analysis of its Dess-Martin oxidation derivative. Compound 1 was evaluated for antilarval settlement activity of barnacle Balanus amphitrite and showed promising antifouling activity with an EC value of 0.103 μM and a high therapeutic ratio of 222.

摘要

对真菌帚霉属（Scopulariopsis sp.）次生代谢产物的进一步化学研究导致发现了一种新的生物碱，帚曲喹诺酮B（1）。通过广泛的核磁共振光谱数据、圆二色光谱及其戴斯-马丁氧化衍生物的分析阐明了化合物1的结构。对化合物1进行了藤壶纹藤壶幼虫附着活性评估，结果显示其具有良好的防污活性，EC值为0.103 μM，治疗指数高达222。