从一种源自硬珊瑚的真菌帚霉属（Scopulariopsis sp.）中分离出的两种新三萜类化合物和一种新萘醌衍生物。
Two new triterpenoids and a new naphthoquinone derivative isolated from a hard coral-derived fungus Scopulariopsis sp.
作者信息
Elnaggar Mohamed S, Ebada Sherif S, Ashour Mohamed L, Ebrahim Weaam, Singab Abdelnasser, Lin Wenhan, Liu Zhen, Proksch Peter
机构信息
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, 40225 Düsseldorf, Germany; Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbassia, Cairo 11566, Egypt.
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbassia, Cairo 11566, Egypt.
出版信息
Fitoterapia. 2017 Jan;116:126-130. doi: 10.1016/j.fitote.2016.12.003. Epub 2016 Dec 5.
Scopulariopsis sp. isolated from the Red Sea hard coral Stylophora sp. yielded two new triterpenoids (1-2) and a new naphthoquinone derivative (8) when cultured on white beans. In addition, fourteen known compounds including three triterpene analogues (3-5), two sesquiterpenoids (6-7), two polyketides (9-10) and seven nitrogenous compounds (11-17) were isolated. All structures were determined through extensive analysis of the NMR and MS data as well as by comparison with literature data. All isolated compounds were evaluated for their cytotoxic, antibacterial and antitubercular activities. However, none of them showed significant activity.
从红海硬珊瑚鹿角杯形珊瑚（Stylophora sp.）中分离出的帚霉属（Scopulariopsis sp.）菌株，在白豆培养基上培养时产生了两种新的三萜类化合物（1-2）和一种新的萘醌衍生物（8）。此外，还分离出了14种已知化合物，包括三种三萜类似物（3-5）、两种倍半萜类化合物（6-7）、两种聚酮化合物（9-10）和七种含氮化合物（11-17）。所有结构均通过对核磁共振（NMR）和质谱（MS）数据的广泛分析以及与文献数据对比得以确定。对所有分离出的化合物进行了细胞毒性、抗菌和抗结核活性评估。然而，它们均未表现出显著活性。
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