a Department of Nutrition/CCS , Federal University of Pernambuco , Campus of Recife, Recife , PE , Brazil.
b Department of Physical Education and Sports Science , Federal University of Pernambuco , Campus of Vitoria de Santo Antao, Vitoria de Santo Antao , PE , Brazil.
Nutr Neurosci. 2018 Dec;21(10):753-760. doi: 10.1080/1028415X.2017.1360549. Epub 2017 Aug 7.
To evaluate how safflower oil (SFO) influences brain electrophysiology and cortical oxidative status in the offspring, mothers received a diet with SFO during brain development period.
Beginning on the 14th day of gestation and throughout lactation, rats received safflower (safflower group - SG) or soybean oil (control group - CG) in their diet. At 65 days old, cortical spreading depression (CSD) and cortex oxidative status were analyzed in the offspring.
SG presented reduction of the CSD velocity as compared to the CG (SG: 3.24 ± 0.09; CG: 3.37 ± 0.07 mm/min). SFO reduced levels of lipid peroxidation by 39.4%. SG showed the following increases: glutathione-S-transferase, 40.8% and reduced glutathione, 34.3%. However, SFO decreased superoxide dismutase by 40.4% and catalase by 64.1%. To control for interhemispheric effects, since CSD was recorded only in the right cortex, we evaluated the oxidative status in both sides of the cortex; no differences were observed.
Data show that when SFO is consumed by the female rats during pregnancy and lactation, the offspring present long-term effects on brain electrophysiology and cortical oxidative state. The present study highlights the relevance of understanding the SFO intake of pregnant and lactating mammals.
评估红花油（SFO）如何影响后代的大脑电生理学和皮质氧化状态，在此期间母亲在大脑发育期接受 SFO 饮食。
从妊娠第 14 天开始并贯穿哺乳期，大鼠饮食中分别添加红花或大豆油。在 65 天大时，分析后代的皮质扩散性抑制（CSD）和皮质氧化状态。
与 CG 相比，SG 的 CSD 速度降低（SG：3.24±0.09；CG：3.37±0.07 mm/min）。SFO 降低了 39.4%的脂质过氧化水平。SG 表现出以下增加：谷胱甘肽-S-转移酶增加 40.8%，还原型谷胱甘肽增加 34.3%。然而，SFO 使超氧化物歧化酶减少 40.4%，过氧化氢酶减少 64.1%。为了控制大脑两侧的半球间效应，由于 CSD 仅在右侧皮质记录，我们评估了两侧皮质的氧化状态；未观察到差异。
数据表明，当雌性大鼠在妊娠和哺乳期食用 SFO 时，后代的大脑电生理学和皮质氧化状态会出现长期影响。本研究强调了了解妊娠和哺乳期哺乳动物 SFO 摄入量的重要性。
