Costa Laís Ribeiro, Macêdo Patrícia Cavalcanti, de Melo Janatar Stella Vasconcelos, Freitas Cristiane Moura, Alves Aiany Simoes, Barbosa Humberto de Moura, Lira Eduardo, Fernandes Mariana Pinheiro, Batista-de-Oliveira-Hornsby Manuella, Lagranha Claudia
a Department of Nutrition/Centro de Ciencias da Saude (CCS). Federal University of Pernambuco, Campus of Recife, Recife, PE 55608-680, Brazil.
b Laboratory of Biochemistry and Exercise Biochemistry, Federal University of Pernambuco, Campus of Vitoria de Santo Antao, Vitoria de Santo Antao, PE, Brazil.
Appl Physiol Nutr Metab. 2016 Dec;41(12):1271-1277. doi: 10.1139/apnm-2016-0191.
Carthamus tinctorius L. (common name: safflower) is an herb whose extracted oil (safflower oil) has been employed in both alternative and conventional medicine in the treatment of disease. Overnutrition during early postnatal life can increase the lifetime risk of obesity and metabolic syndrome. Here we investigate the effect of safflower oil supplementation given during a critical early developmental stage on the eventual occurrence of metabolic disease in overnourished rats. Groups of overnourished or adequately nourished rats were randomly assigned into 2 additional groups for supplementation with either safflower oil (SF) or vehicle for 7 to 30 days. Murinometric data and weights were examined. Serum was collected for measurement of glucose, cholesterol, high-density lipoprotein cholesterol, and triglycerides. Heart and liver oxidative status were also measured. Overnutrition for 7-30 days induced a significant increase in body weight and in values for abdominal circumference, thoracic circumference, body length, and body mass index. SF supplementation did not attenuate the effect of overnutrition on any of these parameters. In addition, overnutrition increased levels of glucose, triglycerides, and very low-density lipid compared with normal controls, but SF supplementation had no effect on these parameters. Measures of oxidative status in heart or liver were not influenced by overnutrition. However, oxidative measures were altered by SF supplementation in both of these organs. The present study reveals that nutritional manipulation during early development induces detrimental effects on metabolism in the adult that are not ameliorated by supplemental SF.
红花（学名：Carthamus tinctorius L.）是一种草本植物，其提取的油（红花油）已被用于替代医学和传统医学中治疗疾病。出生后早期的营养过剩会增加肥胖和代谢综合征的终生风险。在此，我们研究了在关键的早期发育阶段补充红花油对营养过剩大鼠最终发生代谢疾病的影响。将营养过剩或营养充足的大鼠组随机分为另外两组，分别补充红花油（SF）或赋形剂，持续7至30天。检查了测量数据和体重。收集血清以测量葡萄糖、胆固醇、高密度脂蛋白胆固醇和甘油三酯。还测量了心脏和肝脏的氧化状态。7至30天的营养过剩导致体重以及腹围、胸围、体长和体重指数值显著增加。补充SF并未减弱营养过剩对这些参数中任何一个的影响。此外，与正常对照组相比，营养过剩会增加葡萄糖、甘油三酯和极低密度脂蛋白的水平，但补充SF对这些参数没有影响。心脏或肝脏的氧化状态测量不受营养过剩的影响。然而，在这两个器官中，补充SF会改变氧化指标。本研究表明，早期发育期间的营养调控会对成年后的代谢产生有害影响，补充SF并不能改善这种影响。
