巨噬细胞移动抑制因子-1（MIF-1）和酪氨酰-巨噬细胞移动抑制因子-1（Tyr-MIF-1）对阿扑吗啡诱导的大鼠刻板行为的双相效应。
Biphasic effects of MIF-1 and Tyr-MIF-1 on apomorphine-induced stereotypy in rats.
作者信息
Hara C, Kastin A J
出版信息
Pharmacol Biochem Behav. 1986 Oct;25(4):757-61. doi: 10.1016/0091-3057(86)90383-7.
The effects of several doses of MIF-1 and Tyr-MIF-1 (0.2, 0.5, 1.0 and 5.0 mg/kg, SC) on the stereotypic behavior induced by various doses (0.08, 0.2, 0.5, 1.0 and 2.0 mg/kg, SC) of apomorphine (APO) were tested in rats. MIF-1 increased the stereotypic behavior induced by 0.5 and 1.0 mg/kg of APO, but decreased the stereotypic behavior induced by 2.0 mg/kg of APO. Tyr-MIF-1 showed a biphasic effect similar to that exerted by MIF-1. The results suggest that the type of response to MIF-1 and Tyr-MIF-1 after APO is influenced by the activity of central dopaminergic neurons.
在大鼠中测试了几种剂量的巨噬细胞移动抑制因子-1（MIF-1）和酪氨酰-巨噬细胞移动抑制因子-1（Tyr-MIF-1）（0.2、0.5、1.0和5.0毫克/千克，皮下注射）对不同剂量（0.08、0.2、0.5、1.0和2.0毫克/千克，皮下注射）阿扑吗啡（APO）诱导的刻板行为的影响。MIF-1增加了0.5和1.0毫克/千克APO诱导的刻板行为，但减少了2.0毫克/千克APO诱导的刻板行为。Tyr-MIF-1显示出与MIF-1相似的双相效应。结果表明，APO后对MIF-1和Tyr-MIF-1的反应类型受中枢多巴胺能神经元活性的影响。
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