Chen Hao, Klein Robert, Arnold Stacy, Wang Yiying, Chambers Setsuko, Zheng Wenxin
Department of Pathology, University of Arizona College of Medicine.
Department of Obstetrics and Gynecology, Henan Provincial People's Hospital.
J Vis Exp. 2017 Jul 25(125):55887. doi: 10.3791/55887.
Currently, it is widely accepted that the vast majority of ovarian high-grade serous carcinoma (HGSC) originate from the fallopian tube. However, due to the lack of markers or tools for the ovarian cancer identification, the early detection of HGSC remains challenging. Direct sampling of the fallopian tube can enhance sensitivity for detection of neoplastic cells when the tumor is not grossly visible. We developed a procedure to collect fallopian tube cells directly from freshly received surgical specimens, which has shown excellent correlation with histological findings. This approach lays a foundation for the future utility of minimally invasive laparoscopic screening in high-risk patient populations.
目前，人们普遍认为绝大多数卵巢高级别浆液性癌（HGSC）起源于输卵管。然而，由于缺乏用于卵巢癌识别的标志物或工具，HGSC的早期检测仍然具有挑战性。当肿瘤肉眼不可见时，直接对输卵管进行采样可以提高对肿瘤细胞检测的敏感性。我们开发了一种从新鲜获取的手术标本中直接收集输卵管细胞的方法，该方法已显示出与组织学结果具有极好的相关性。这种方法为未来在高危患者群体中进行微创腹腔镜筛查奠定了基础。
