Srivastava M D, Bhargava A K
Acta Haematol. 1986;76(1):25-8. doi: 10.1159/000206013.
The specificity of the expression of dipeptidylaminopeptidase-IV (DAP-IV) was examined in cells from leukemia patients and in 33 normal and leukemic human cell lines widely used in various studies. There was no correlation between DAP-IV activity and OKT4 positivity or maturation stage in T cells. In addition, DAP-IV was unexpectedly expressed by 4 B cell lines and 1 histiocytic lymphoma cell line, indicating either lack of specificity of DAP-IV or infidelity of gene expression under unnatural culture environment.
在白血病患者的细胞以及33种广泛用于各类研究的正常和白血病人类细胞系中，检测了二肽基氨基肽酶-IV（DAP-IV）表达的特异性。DAP-IV活性与T细胞中的OKT4阳性或成熟阶段之间没有相关性。此外，4种B细胞系和1种组织细胞淋巴瘤细胞系意外地表达了DAP-IV，这表明要么DAP-IV缺乏特异性，要么在非自然培养环境下基因表达不忠实。
