Vanella A, Campisi A, Guglielmo P, Cacciola E, Cunsolo F, Geremia E, Tiriolo P, Pappalardo P, Crisafi G
Acta Haematol. 1986;76(1):33-6. doi: 10.1159/000206015.
Ornithine decarboxylase (L-ornithine carboxylase, EC 4.1.1.17) and transglutaminase (R-glutaminylpeptide: amine gamma-glutamyltransferase, EC 2.3.2.13), enzymes implicated in the regulation of growth processes, were studied in lymphocytes from untreated patients with chronic lymphocytic leukemia. A marked increase of ornithine decarboxylase activity was found in lymphocytes from chronic lymphocytic leukemia patients when compared to normal human lymphocytes; in contrast, no transglutaminase activity was found in lymphocytes from untreated patients with chronic lymphocytic leukemia.
鸟氨酸脱羧酶（L-鸟氨酸羧酶，EC 4.1.1.17）和转谷氨酰胺酶（R-谷氨酰胺基肽：胺γ-谷氨酰转移酶，EC 2.3.2.13）是与生长过程调节有关的酶，对未经治疗的慢性淋巴细胞白血病患者的淋巴细胞进行了研究。与正常人淋巴细胞相比，慢性淋巴细胞白血病患者淋巴细胞中的鸟氨酸脱羧酶活性显著增加；相反，未经治疗的慢性淋巴细胞白血病患者的淋巴细胞中未发现转谷氨酰胺酶活性。
