放线菌素D和胍对口蹄疫病毒诱导的核糖核酸聚合酶形成以及病毒和病毒核糖核酸复制的影响。
Effect of actinomycin D and guanidine on the formation of a ribonucleic acid polymerase induced by foot-and mouth-disease virus and on the replication of virus and viral ribonucleic acid.
作者信息
Black D N, Brown F
出版信息
Biochem J. 1969 Apr;112(3):317-23. doi: 10.1042/bj1120317.
Abstract
The RNA-dependent RNA polymerase induced in baby-hamster kidney cells by infection with foot-and-mouth-disease virus can be detected as early as 60min. after infection, which is 60min. before viral RNA synthesis commences. The time at which the polymerase can first be detected coincides with the latest time at which actinomycin D (50mug./10(7) cells) or guanidine (1mg./10(7) cells) inhibits virus replication. However, by increasing the concentration of guanidine, viral replication can be inhibited later in the growth cycle, casting doubt on the validity of the hypothesis that guanidine acts specifically on the formation of the viral RNA polymerase.
摘要
感染口蹄疫病毒后在幼仓鼠肾细胞中诱导产生的依赖RNA的RNA聚合酶最早在感染后60分钟即可检测到，这比病毒RNA合成开始早60分钟。首次检测到该聚合酶的时间与放线菌素D（50μg/10⁷个细胞）或胍（1mg/10⁷个细胞）抑制病毒复制的最晚时间一致。然而，通过增加胍的浓度，病毒复制可在生长周期的后期受到抑制，这使人对胍特异性作用于病毒RNA聚合酶形成这一假说的有效性产生怀疑。
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