Dhoat Sasha, Ali Khalid, Bulpitt Christopher J, Rajkumar Chakravarthi
Faculty of Medicine, Imperial College, London, UK.
Age Ageing. 2008 Nov;37(6):653-9. doi: 10.1093/ageing/afn158. Epub 2008 Aug 13.
to determine whether functional changes in the vasculature differ between Alzheimer's disease (AD) and vascular dementia (VAD).
we determined vascular stiffness in patients with a clinical and radiological diagnosis of either AD or VAD and compared them to normal age- and sex-matched controls.
In all, 16 patients with late onset AD, 13 subjects with VAD and 16 age- and sex-matched controls were recruited to this study. Central arterial compliance (CAC), augmentation index (AI) and pulse wave velocity (PWV) (measures of arterial stiffness) were measured.
the mean age was 77.7 +/- 8.3 years (mean +/- SD) in the AD group, 79.7 +/- 8.9 years in the VAD group and 76.4 +/- 6.9 in the controls (P = 0.44). CAC was significantly lower in subjects with VAD compared to both the AD and the control groups (0.57 +/- 0.46 ml/mm Hg versus 1.12 +/- 0.57 and 1.1 +/- 0.47 ml/mm Hg respectively, P = 0.01). AI was significantly higher in the subjects with VAD compared to both the AD and the control groups (13.3 +/- 9.0 versus 3.5 +/- 11.4 and 4.2 +/- 9.7% respectively, P = 0.03). PWV in the muscular and elastic arteries were not statistically different between the three groups but tended to be highest in the VAD group for carotid-radial measurements.
the reduced CAC and increased AI in VAD subjects indicate that the disease process is associated with less vascular compliance of the large elastic arteries in these patients, but not in patients with AD.
确定阿尔茨海默病（AD）和血管性痴呆（VAD）患者血管系统的功能变化是否存在差异。
我们测定了临床和影像学诊断为AD或VAD的患者的血管僵硬度，并将其与年龄和性别匹配的正常对照组进行比较。
本研究共招募了16例晚发型AD患者、13例VAD患者和16例年龄及性别匹配的对照组。测量了中心动脉顺应性（CAC）、增强指数（AI）和脉搏波速度（PWV）（动脉僵硬度的测量指标）。
AD组的平均年龄为77.7±8.3岁（平均值±标准差），VAD组为79.7±8.9岁，对照组为76.4±6.9岁（P = 0.44）。与AD组和对照组相比，VAD患者的CAC显著降低（分别为0.57±0.46 ml/mm Hg、1.12±0.57和1.1±0.47 ml/mm Hg，P = 0.01）。与AD组和对照组相比，VAD患者的AI显著升高（分别为13.3±9.0、3.5±11.4和4.2±9.7%，P = 0.03）。三组之间肌肉动脉和弹性动脉的PWV无统计学差异，但在颈动脉-桡动脉测量中，VAD组的PWV往往最高。
VAD患者CAC降低和AI升高表明，该疾病过程与这些患者大弹性动脉的血管顺应性降低有关，而AD患者则不然。
