窦房结疾病患者口服xamoterol的研究
Oral xamoterol in patients with sinoatrial disease.
作者信息
Tseu F L, Morley C A, Mackintosh A F
出版信息
Br Heart J. 1986 Nov;56(5):469-72. doi: 10.1136/hrt.56.5.469.
Abstract
Twelve patients with sinoatrial disease were assessed while on oral xamoterol (200 mg twice daily) and placebo by a double blind randomised, crossover trial that lasted four weeks. Nine of the patients had been referred for permanent pacing. Xamoterol produced favourable changes in the number of pauses and the mean heart rate in six patients. Another patient deteriorated on xamoterol. Six patients were started on long term xamoterol. Xamoterol produces short term electrocardiographic improvement in some, but not all, patients with symptomatic sinoatrial disease.
摘要
通过一项为期四周的双盲随机交叉试验，对12例患有窦房疾病的患者在服用口服昔莫洛尔（每日两次，每次200毫克）和安慰剂期间进行了评估。其中9例患者已被转诊接受永久性起搏治疗。昔莫洛尔使6例患者的停搏次数和平均心率出现了有利变化。另有1例患者在服用昔莫洛尔后病情恶化。6例患者开始长期服用昔莫洛尔。昔莫洛尔可使部分（而非全部）有症状的窦房疾病患者短期内心电图得到改善。
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本文引用的文献
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Electrophysiologic effects of theophylline in young patients with recurrent symptomatic bradyarrhythmias.
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Mean 24 hour heart rate, minimal heart rate and pauses in healthy subjects 40-79 years of age.40至79岁健康受试者的24小时平均心率、最低心率及停搏情况。
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