Kocacik Uygun Dilara F, Uygun Vedat, Daloğlu Hayriye, Öztürkmen Seda I, Karasu Gülsün T, Hazar Volkan, Yeşilipek Akif
Department of Pediatric Immunology, Antalya Training and Research Hospital.
Department of Pediatric Bone Marrow Transplantation Unit, MedicalPark Antalya Hospital.
J Pediatr Hematol Oncol. 2018 Apr;40(3):e179-e181. doi: 10.1097/MPH.0000000000000923.
Immune reconstitution inflammatory syndrome (IRIS) is a clinical condition emerging after immune recovery of an immunocompromised status, mostly in human immunodeficiency virus infected patients but also in several other settings, such as the recovery from the severe combined immunodeficiency status after hematopoietic stem cell transplantation. Herein, we report a patient transplanted for severe combined immunodeficiency who developed IRIS for 2 times, namely shortly after transplantation and after donor lymphocyte infusion. Pediatric transplant teams need to be aware of the previous IRIS phenomenon of BCG-adenitis while making the decision of donor lymphocyte infusions.
免疫重建炎症综合征（IRIS）是一种在免疫功能低下状态免疫恢复后出现的临床病症，主要见于人类免疫缺陷病毒感染患者，但也见于其他一些情况，如造血干细胞移植后从严重联合免疫缺陷状态恢复时。在此，我们报告一名因严重联合免疫缺陷接受移植的患者，该患者发生了2次IRIS，分别在移植后不久和供体淋巴细胞输注后。儿科移植团队在决定进行供体淋巴细胞输注时需要了解此前卡介苗淋巴结炎的IRIS现象。
