免疫重建炎症综合征作为播散性鸟分枝杆菌原发性免疫缺陷移植后的并发症
Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium.
作者信息
Manion Maura, Dimitrova Dimana, Pei Luxin, Gea-Banacloche Juan, Zelazny Adrian, Lisco Andrea, Zerbe Christa, Freeman Alexandra F, Holland Steven M, Kanakry Christopher G, Kanakry Jennifer A, Sereti Irini
机构信息
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
出版信息
Clin Infect Dis. 2020 Feb 3;70(4):676-679. doi: 10.1093/cid/ciz507.
Abstract
Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.
摘要
因难以控制的感染而接受异基因造血细胞移植（HCT）的原发性免疫缺陷患者在植入后可能会出现免疫重建炎症综合征（IRIS）。在3例与分枝杆菌感染相关的HCT后IRIS患者中，体外数据显示出现了病原体特异性免疫反应，同时血浆炎症标志物也随之升高。
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