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本文引用的文献

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Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS.泼尼松预防结核分枝杆菌潜伏感染相关的矛盾性免疫重建炎症综合征。
N Engl J Med. 2018 Nov 15;379(20):1915-1925. doi: 10.1056/NEJMoa1800762.
2
Emergence of Polyfunctional Cytotoxic CD4+ T Cells in Mycobacterium avium Immune Reconstitution Inflammatory Syndrome in Human Immunodeficiency Virus-Infected Patients.分枝杆菌免疫重建炎症综合征患者中多功能细胞毒性 CD4+T 细胞的出现与人类免疫缺陷病毒感染有关。
Clin Infect Dis. 2018 Jul 18;67(3):437-446. doi: 10.1093/cid/ciy016.
3
Recurrent arthritis and immune reconstitution inflammatory syndrome in hematopoietic stem cell transplantation (HSCT).造血干细胞移植（HSCT）中的复发性关节炎和免疫重建炎症综合征
Bone Marrow Transplant. 2018 Mar;53(3):374-376. doi: 10.1038/s41409-017-0058-4. Epub 2017 Dec 21.
4
Immune Reconstitution Inflammatory Syndrome After DLI in a SCID Patient After Hematopoetic Stem Cell Transplantation.造血干细胞移植后重度联合免疫缺陷患者接受供者淋巴细胞输注后的免疫重建炎性综合征
J Pediatr Hematol Oncol. 2018 Apr;40(3):e179-e181. doi: 10.1097/MPH.0000000000000923.
5
Enterovirus-Related Immune Reconstitution Inflammatory Syndrome (IRIS) Following Haploidentical Stem Cell Transplantation in an MHC Class II-Deficient Child.一名MHC II类缺陷儿童单倍体干细胞移植后发生的肠道病毒相关免疫重建炎症综合征（IRIS）
J Clin Immunol. 2017 Jul;37(5):419-421. doi: 10.1007/s10875-017-0402-x. Epub 2017 May 16.
6
HIV infection and immune activation: the role of coinfections.艾滋病毒感染与免疫激活：合并感染的作用
Curr Opin HIV AIDS. 2016 Mar;11(2):191-200. doi: 10.1097/COH.0000000000000241.
7
HIV-tuberculosis-associated immune reconstitution inflammatory syndrome is characterized by Toll-like receptor and inflammasome signalling.人类免疫缺陷病毒-结核相关免疫重建炎症综合征的特征为Toll样受体和炎性小体信号传导。
Nat Commun. 2015 Sep 24;6:8451. doi: 10.1038/ncomms9451.
8
Immune reconstitution inflammatory syndrome in neutropenic patients with invasive pulmonary aspergillosis.中性粒细胞减少症合并侵袭性肺曲霉病患者的免疫重建炎症综合征。
J Infect. 2015 Jun;70(6):659-67. doi: 10.1016/j.jinf.2014.12.020. Epub 2015 Jan 15.
9
Plasma interleukin-18 levels are a biomarker of innate immune responses that predict and characterize tuberculosis-associated immune reconstitution inflammatory syndrome.血浆白细胞介素-18水平是先天性免疫反应的生物标志物，可预测和表征与结核病相关的免疫重建炎症综合征。
AIDS. 2015 Feb 20;29(4):421-31. doi: 10.1097/QAD.0000000000000557.
10
Mycobacterial antigen driven activation of CD14++CD16- monocytes is a predictor of tuberculosis-associated immune reconstitution inflammatory syndrome.分枝杆菌抗原驱动的CD14++CD16-单核细胞激活是结核病相关免疫重建炎症综合征的一个预测指标。
PLoS Pathog. 2014 Oct 2;10(10):e1004433. doi: 10.1371/journal.ppat.1004433. eCollection 2014 Oct.

免疫重建炎症综合征作为播散性鸟分枝杆菌原发性免疫缺陷移植后的并发症

Immune Reconstitution Inflammatory Syndrome as a Posttransplantation Complication in Primary Immunodeficiency With Disseminated Mycobacterium avium.

作者信息

Manion Maura, Dimitrova Dimana, Pei Luxin, Gea-Banacloche Juan, Zelazny Adrian, Lisco Andrea, Zerbe Christa, Freeman Alexandra F, Holland Steven M, Kanakry Christopher G, Kanakry Jennifer A, Sereti Irini

机构信息

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.

National Cancer Institute, National Institutes of Health, Bethesda, Maryland.

出版信息

Clin Infect Dis. 2020 Feb 3;70(4):676-679. doi: 10.1093/cid/ciz507.

DOI:10.1093/cid/ciz507
PMID:31190050
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7319264/
Abstract

Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.

摘要

因难以控制的感染而接受异基因造血细胞移植（HCT）的原发性免疫缺陷患者在植入后可能会出现免疫重建炎症综合征（IRIS）。在3例与分枝杆菌感染相关的HCT后IRIS患者中，体外数据显示出现了病原体特异性免疫反应，同时血浆炎症标志物也随之升高。