Manion Maura, Dimitrova Dimana, Pei Luxin, Gea-Banacloche Juan, Zelazny Adrian, Lisco Andrea, Zerbe Christa, Freeman Alexandra F, Holland Steven M, Kanakry Christopher G, Kanakry Jennifer A, Sereti Irini
National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
Clin Infect Dis. 2020 Feb 3;70(4):676-679. doi: 10.1093/cid/ciz507.
Patients with primary immunodeficiencies undergoing allogeneic hematopoietic cell transplantation (HCT) for difficult-to-control infections can experience immune reconstitution inflammatory syndrome (IRIS) following engraftment. In 3 patients with post-HCT IRIS related to mycobacterial infection, in vitro data demonstrate the emergence of pathogen-specific immune responses and a concomitant rise in plasma inflammatory markers.
因难以控制的感染而接受异基因造血细胞移植(HCT)的原发性免疫缺陷患者在植入后可能会出现免疫重建炎症综合征(IRIS)。在3例与分枝杆菌感染相关的HCT后IRIS患者中,体外数据显示出现了病原体特异性免疫反应,同时血浆炎症标志物也随之升高。