聚（N-异丙基丙烯酰胺）-b-聚（L-赖氨酸盐酸盐）和聚（N-异丙基丙烯酰胺-共-丙烯酰胺）-b-聚（L-赖氨酸盐酸盐）的合成与相行为

Synthesis and Phase Behavior of Poly(-isopropylacrylamide)-b- Poly(L-Lysine Hydrochloride) and Poly(-Isopropylacrylamide- co-Acrylamide)-b-Poly(L-Lysine Hydrochloride).

作者信息

Spasojević Milica, Vorenkamp Joop, Jansen Mark R P A C S, de Vos Paul, Schouten Arend Jan

机构信息

Department of Polymer Chemistry, Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.

Department of Pathology and Medical Biology, Section of Immunoendocrinology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, EA11, 9700 RB Groningen, The Netherlands.

出版信息

Materials (Basel). 2014 Jul 22;7(7):5305-5326. doi: 10.3390/ma7075305.

DOI:10.3390/ma7075305

PMID:28788130

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5455825/

Abstract

The synthesis of poly(-isopropylacrylamide)-b-poly(L-lysine) and poly(- isopropylacrylamide-co-acrylamide)-b-poly(L-lysine) copolymers was accomplished by combining atom transfer radical polymerization (ATRP) and ring opening polymerization (ROP). For this purpose, a di-functional initiator with protected amino group was successfully synthetized. The ATRP of -isopropylacrylamide yielded narrowly dispersed polymers with consistent high yields (~~80%). Lower yields (~~50%) were observed when narrowly dispersed random copolymers of -isopropylacrylamide and acrylamide where synthesized. Amino-terminated poly(-isopropylacrylamide) and poly(-isopropylacrylamide- co-acrylamide) were successfully used as macroinitiators for ROP of ₆-carbobenzoxy-L- lysine -carboxyanhydride. The thermal behavior of the homopolymers and copolymers in aqueous solutions was studied by turbidimetry, dynamic light scattering (DLS) and proton nuclear magnetic resonance spectroscopy (¹H-NMR).

摘要

通过结合原子转移自由基聚合（ATRP）和开环聚合（ROP）实现了聚（N-异丙基丙烯酰胺）-b-聚（L-赖氨酸）和聚（N-异丙基丙烯酰胺-共-丙烯酰胺）-b-聚（L-赖氨酸）共聚物的合成。为此，成功合成了一种带有保护氨基的双官能引发剂。N-异丙基丙烯酰胺的ATRP产生了窄分布的聚合物，产率始终很高（约80%）。当合成N-异丙基丙烯酰胺和丙烯酰胺的窄分布无规共聚物时，产率较低（约50%）。氨基封端的聚（N-异丙基丙烯酰胺）和聚（N-异丙基丙烯酰胺-共-丙烯酰胺）成功用作6-苄氧羰基-L-赖氨酸-N-羧酸酐ROP的大分子引发剂。通过比浊法、动态光散射（DLS）和质子核磁共振光谱（¹H-NMR）研究了均聚物和共聚物在水溶液中的热行为。