不同氧含量掺杂的Ti-35Nb-7Zr-5Ta合金的细胞毒性

Cytotoxicity of a Ti-35Nb-7Zr-5Ta Alloy Doped with Different Oxygen Contents.

作者信息

Donato Tatiani Ayako Goto, de Almeida Luciano Henrique, Arana-Chavez Victor Elias, Grandini Carlos Roberto

机构信息

UNESP-Univ. Estadual Paulista, Laboratório de Anelasticidade e Biomateriais, 17.033-360, Bauru, SP, Brazil.

USP-Universidade de São Paulo, Faculdade de Odontologia, Departamento de Biomateriais e Biologia Oral, 05.508-900, São Paulo, SP, Brazil.

出版信息

Materials (Basel). 2014 Mar 13;7(3):2183-2193. doi: 10.3390/ma7032183.

DOI:10.3390/ma7032183

PMID:28788562

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5453255/

Abstract

Cp-Ti is the most common material used for dental implants, but its elastic modulus is around five times higher than that of bone. Recently, promising alloys that add Nb, Ta, Zr and Mo to Ti have been developed. The mechanical properties of these alloys are directly related to its microstructure and the presence of interstitial elements, such as oxygen, carbon, nitrogen and hydrogen. In this study, the cytotoxicity of Ti-35Nb-7Zr-5Ta (TNZT) alloys was analyzed in the as-received condition and after being doped with several small quantities of oxygen on a cultured osteogenic cell. The cell's morphology was also examined by scanning electron microscopy (SEM). The TNZT alloy presented no cytotoxic effects on osteoblastic cells in the studied conditions.

摘要

Cp钛是用于牙种植体最常用的材料，但其弹性模量比骨的弹性模量高约五倍。最近，已开发出向钛中添加铌、钽、锆和钼的有前景的合金。这些合金的力学性能与其微观结构以及间隙元素（如氧、碳、氮和氢）的存在直接相关。在本研究中，分析了Ti-35Nb-7Zr-5Ta（TNZT）合金在初始状态以及在培养的成骨细胞上掺杂少量氧气后的细胞毒性。还通过扫描电子显微镜（SEM）检查了细胞形态。在所研究的条件下，TNZT合金对成骨细胞没有细胞毒性作用。