Rueda-Orozco Pavel E, Montes-Rodriguez Corinne J, Ruiz-Contreras Alejandra E, Mendez-Diaz Monica, Prospero-Garcia Oscar
Departamento de Neurofisiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, UNAM, Mexico.
Departamento de Neurobiología y Neurociencias, Facultad de Psicología, UNAM, Mexico.
Brain Res. 2017 Oct 1;1672:129-136. doi: 10.1016/j.brainres.2017.08.002. Epub 2017 Aug 5.
Cannabinergic receptor 1 (CB1r) is highly expressed in almost the entire brain; hence, its activation affects diverse functions, including cognitive processes such as learning and memory. On the other hand, it has been demonstrated that CB1r expression fluctuates along the light-dark cycle. In this context, the objective of this work was to characterize the cannabinergic influence over cognitive processes and its relationship with the light-dark cycle. To this aim we studied the effects of two endogenous cannabinoids, anandamide (AEA) and oleamide (ODA), on the consolidation of memory and event-related potentials (ERPs) depending on the light-dark cycle. Our results indicate that AEA and ODA impair the consolidation of spatial and emotional memories and reduce the amplitude of several components of the ERP complex, depending on the phase of the light-dark cycle. This study further supports the notion that endocannabinoids participate in the regulation of cognitive processes with strong influence of environmental variables such as the light-dark cycle.
大麻素受体1（CB1r）在几乎整个大脑中都高度表达；因此，其激活会影响多种功能，包括学习和记忆等认知过程。另一方面，已经证明CB1r的表达会随着昼夜交替周期而波动。在此背景下，本研究的目的是确定大麻素对认知过程的影响及其与昼夜交替周期的关系。为此，我们研究了两种内源性大麻素，花生四烯乙醇胺（AEA）和油酰胺（ODA），在昼夜交替周期不同阶段对记忆巩固和事件相关电位（ERP）的影响。我们的结果表明，根据昼夜交替周期的阶段，AEA和ODA会损害空间记忆和情感记忆的巩固，并降低ERP复合体几个成分的振幅。这项研究进一步支持了内源性大麻素参与认知过程调节的观点，且环境变量如昼夜交替周期对此有强烈影响。
