腺苷受体拮抗剂8-苯基茶碱可使大鼠产生利尿和利钠作用。
The adenosine receptor antagonist, 8-phenyltheophylline, causes diuresis and saliuresis in the rat.
作者信息
Collis M G, Baxter G S, Keddie J R
出版信息
J Pharm Pharmacol. 1986 Nov;38(11):850-2. doi: 10.1111/j.2042-7158.1986.tb04510.x.
The diuretic and adenosine antagonist actions of two alkylxanthines have been compared in the conscious rat. 8-Phenyltheophylline (10 mg kg-1) antagonized adenosine-induced bradycardia in the rat for at least 3 h whereas enprofylline (10 mg kg-1) had no effect on this response. 8-Phenyltheophylline (10 mg kg-1) evoked diuresis and saliuresis in the rat whereas enprofylline (10 mg kg-1) had no effect on excretory parameters. These results indicate that the diuretic action of some alkylxanthines may be related to adenosine antagonism.
在清醒大鼠中比较了两种烷基黄嘌呤的利尿和腺苷拮抗作用。8-苯基茶碱（10毫克/千克）拮抗大鼠体内腺苷诱导的心动过缓至少3小时，而恩丙茶碱（10毫克/千克）对该反应无影响。8-苯基茶碱（10毫克/千克）引起大鼠利尿和利涎，而恩丙茶碱（10毫克/千克）对排泄参数无影响。这些结果表明，某些烷基黄嘌呤的利尿作用可能与腺苷拮抗作用有关。
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