Varma P P, Seth A K, Malik R, Mahapatra C, Rana Pvs
Classified Specialist (Medicine & Nephrology), Command Hospital (Eastern Command), Calcutta-700 027.
Classified Specialist (Medicine & Gastroenterology), Command Hospital (Eastern Command), Calcutta-700 027.
Med J Armed Forces India. 2000 Oct;56(4):296-297. doi: 10.1016/S0377-1237(17)30212-5. Epub 2017 Jun 12.
Only 20-50% of hemodialysis patients, develop protective antibodies following double dose Hepatitis B vaccination. Early reports suggest augmented response with concomitant use of Granulocyte macrophage colony stimulating factor (GMCSF). This study was done to assess the response rate to hepatitis B vaccine in hemodialysis patients with use of GMCSF. Seventeen patients were included in study, all received 40 mcg of hepatitis B vaccine at 0,1 and 2 months. Ten of these received 150 mcg of GMCSF with each dose of vaccine while 7 were taken as controls. Only one patient from control group (14.3%) while 5/10 (50%) patients from GMCSF group, developed protective antibodies, i.e. anti HBS titres > 10miu/ml (p < 0.05). Present study shows the beneficial effect of GMCSF when used as adjuvant with hepatitis B vaccine, in hemodialysis patients.