血浆纤维蛋白原和血清白蛋白水平（FA评分）是非小细胞肺癌中一种很有前景的预后指标。

Plasma fibrinogen and serum albumin levels (FA score) act as a promising prognostic indicator in non-small cell lung cancer.

作者信息

Chen Pengxiang, Wang Cong, Cheng Bo, Nesa Effat Un, Liu Yuan, Jia Yibin, Qu Yan, Jiang Ziying, Han Jie, Cheng Yufeng

机构信息

Department of Radiation Oncology, Qilu Hospital of Shandong University, Jinan.

Medical College of Qingdao University, Qingdao.

出版信息

Onco Targets Ther. 2017 Jun 21;10:3107-3118. doi: 10.2147/OTT.S138854. eCollection 2017.

BACKGROUND

Evidence implies that preoperative plasma fibrinogen and serum albumin are associated with cancer prognosis. We aimed to explore the prognostic values of the score based on plasma fibrinogen and serum albumin levels (FA score) in non-small cell lung cancer (NSCLC), and to compare that with prognostic nutritional index (PNI).

PATIENTS AND METHODS

In all, 182 patients pathologically diagnosed with NSCLC were included in this study. Kaplan-Meier survival analysis and multivariate analysis were used in the prognostic analyses.

RESULTS

High FA score was related to smoking (=0.005), poor differential grade (=0.002), and advanced T stage (<0.001) and tumor, node, and metastases stage (=0.011). Low PNI showed association with advanced T stage (=0.030). Kaplan-Meier survival analysis indicated that high FA score and low PNI were associated with poor progression-free survival (PFS; for the FA score, <0.001; for PNI, =0.001) and overall survival (OS; for the FA score, <0.001; for PNI, =0.013), respectively. Multivariate analysis revealed that FA score was an independent predictor for PFS (=0.003) and OS (=0.001) in NSCLC patients.

CONCLUSION

The FA score could act as a more promising prognostic predictor than PNI in NSCLC patients who underwent pneumonectomy.

背景

有证据表明术前血浆纤维蛋白原和血清白蛋白与癌症预后相关。我们旨在探讨基于血浆纤维蛋白原和血清白蛋白水平的评分（FA评分）在非小细胞肺癌（NSCLC）中的预后价值，并将其与预后营养指数（PNI）进行比较。

患者与方法

本研究共纳入182例经病理诊断为NSCLC的患者。预后分析采用Kaplan-Meier生存分析和多因素分析。

结果

高FA评分与吸烟（=0.005）、分化差（=0.002）、T分期晚（<0.001）以及肿瘤、淋巴结和转移分期（=0.011）相关。低PNI与T分期晚（=0.030）有关。Kaplan-Meier生存分析表明，高FA评分和低PNI分别与无进展生存期（PFS；FA评分，<0.001；PNI，=0.001）和总生存期（OS；FA评分，<0.001；PNI，=0.013）差相关。多因素分析显示，FA评分是NSCLC患者PFS（=0.003）和OS（=0.001）的独立预测因素。