He Zong-Bao, Lv You-Kui, Li Hui, Yao Qiong, Wang Ke-Ming, Song Xiao-Ge, Wu Zi-Jian, Qin Ximing
Department of Rehabilitation, Anhui People's Armed Police Corps Hospital, Hefei, Anhui 230041, China.
School of Acupuncture and Osteology, Anhui University of Traditional Chinese Medicine, Hefei, Anhui 230038, China.
Biomed Res Int. 2017;2017:5986957. doi: 10.1155/2017/5986957. Epub 2017 Jul 16.
Atlantoaxial disorders are often correlated with hypertension in practice. In order to study the relationship between atlantoaxial disorder and hypertension, we attempted to construct an animal model. In this work, we presented an animal model where their atlantoaxial joints were misaligned. We investigated the changes of blood pressure before and after treatments of the modeled rats. We had the following results. (1) SBP and DBP of each surgery group were significantly higher than those of control and sham groups. (2) After the second operation (the fixture was removed), SBP and DBP of both surgery groups decreased and got closer to the control and sham groups after 7 days. (3) Heart rates got significantly higher in both surgery groups, compared to control and sham groups. (4) The blood Ach levels of the surgery groups were significantly lower than those of control and sham groups. With these results, we concluded that we successfully constructed cervical atlantoaxial disorder models in rats that showed hypertension symptom. However, the underlying mechanism connecting atlantoaxial disorder and hypertension still requires further study.
在实际中，寰枢椎疾病常与高血压相关。为研究寰枢椎疾病与高血压之间的关系，我们试图构建一个动物模型。在这项工作中，我们呈现了一个寰枢椎关节错位的动物模型。我们研究了建模大鼠治疗前后血压的变化。我们得到了以下结果。（1）各手术组的收缩压和舒张压均显著高于对照组和假手术组。（2）第二次手术后（移除固定装置），两个手术组的收缩压和舒张压均下降，7天后接近对照组和假手术组。（3）与对照组和假手术组相比，两个手术组的心率显著更高。（4）手术组的血液乙酰胆碱水平显著低于对照组和假手术组。基于这些结果，我们得出结论，我们成功构建了表现出高血压症状的大鼠颈椎寰枢椎疾病模型。然而，连接寰枢椎疾病和高血压的潜在机制仍需进一步研究。
