Vetcher Alexandre A, Zhukov Kirill V, Gasparyan Bagrat A, Borovikov Pavel I, Karamian Arfenia S, Rejepov Dovlet T, Kuznetsova Maria N, Shishonin Alexander Y
Complementary and Integrative Health Clinic of Dr. Shishonin, 5 Yasnogorskaya Str., 117588 Moscow, Russia.
Institute of Biochemical Technology and Nanotechnology, Peoples' Friendship University of Russia, n.a. P. Lumumba (RUDN), 6 Miklukho-Maklaya St., 117198 Moscow, Russia.
Biomedicines. 2023 Jul 30;11(8):2147. doi: 10.3390/biomedicines11082147.
We recently reported that the restoration of cervical vertebral arterial blood flow access (measured as systolic peak (PS)) to the rhomboid fossa leads to the recovery of the HbA1c level in the case of patients with a pre-Diabetes Mellitus (pre-DM) condition. The theory of centralized aerobic-anaerobic energy balance compensation (TCAAEBC) provides a successful theoretical explanation for this observation. It considers the human body as a dissipative structure. Reported connections between arterial hypertension (AHT) and the level of HbA1c are linked through OABFRH. According to the TCAAEBC, this delivers incorrect information about blood oxygen availability to the cerebellum. The restoration of PS normalizes AHT in 5-6 weeks and HbA1c in 12-13 weeks. In the current study, we demonstrate the model which fits the obtained experimental data. According to the model, pathways of onset and recovery from pre-DM are different. The consequence of these differences is discussed. The great significance of the TCAAEBC for medical practice forces the creation of an appropriate mathematical model, but the required adjustment of the model needs experimental data which can only be obtained from an animal model(s). The essential part of this study is devoted to the analysis of the advantages and disadvantages of widely available common mammalian models for TCAAEBC cases.
我们最近报告称，对于处于糖尿病前期（pre-DM）状态的患者，恢复菱形窝的颈椎动脉血流通路（以收缩期峰值（PS）衡量）可使糖化血红蛋白（HbA1c）水平恢复正常。集中式有氧-无氧能量平衡补偿理论（TCAAEBC）为这一观察结果提供了成功的理论解释。该理论将人体视为一个耗散结构。动脉高血压（AHT）与HbA1c水平之间的已知联系是通过OABFRH建立的。根据TCAAEBC，这会向小脑传递有关血氧可用性的错误信息。PS的恢复可在5至6周内使AHT恢复正常，在12至13周内使HbA1c恢复正常。在当前研究中，我们展示了符合所获实验数据的模型。根据该模型，pre-DM的发病和恢复途径不同。讨论了这些差异的后果。TCAAEBC对医学实践具有重大意义，这促使我们创建一个合适的数学模型，但模型的必要调整需要实验数据，而这些数据只能从动物模型中获得。本研究的重要部分致力于分析广泛使用的常见哺乳动物模型在TCAAEBC案例中的优缺点。
