Chatterjee Samrat, Agrawal Deepshikha
Consultants, Cornea and Anterior Segment Service, MGM Eye Institute, Raipur, Chhattisgarh.
J Assoc Physicians India. 2017 Jul;65(7):110-111.
The ocular side-effects of bisphosphonates have the potential to escalate with their widespread use. We report a patient of osteoporosis who was treated with zoledronic acid infusion. He developed ocular pain, redness, watering, photophobia and swelling of both the eyes. He was diagnosed with acute anterior uveitis and conjunctivitis and treated with topical 1% prednisolone acetate and 1% atropine sulphate. The signs of inflammation abated by one week and the steroids were tapered over the next six weeks. There were no further recurrences. Patients must be educated about the ocular side-effects of bisphosphonate therapy, monitored closely after intravenous infusion and advised to seek ophthalmic consultation promptly if any ocular symptoms or signs develop.
双膦酸盐类药物的眼部副作用可能会随着其广泛使用而增多。我们报告一名骨质疏松症患者，接受了唑来膦酸静脉输注治疗。他出现了眼痛、眼红、流泪、畏光以及双眼肿胀。他被诊断为急性前葡萄膜炎和结膜炎，并接受了局部使用1%醋酸泼尼松龙和1%硫酸阿托品的治疗。炎症体征在一周后减轻，类固醇药物在接下来的六周内逐渐减量。此后未再复发。必须对患者进行双膦酸盐治疗眼部副作用方面的教育，静脉输注后密切监测，若出现任何眼部症状或体征，建议其立即寻求眼科会诊。
