Umunakwe Obi C, Herren David, Kim Stephen J, Kohanim Sahar
Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee.
Digit J Ophthalmol. 2017 Dec 28;23(4):18-21. doi: 10.5693/djo.02.2017.08.002. eCollection 2017.
Bisphosphonates have become a commonly used class of medications to treat osteoporosis and other bone diseases. Zoledronate (zoledronic acid) can be dosed annually via intravenous infusion, making it an appealing option for patients and physicians. We report the case of a 68-year-old woman who developed severe, unilateral, ocular inflammation, including corneal endotheliitis, anterior uveitis with hyphema, scleritis, and orbital inflammation beginning 12 hours after receiving her first zoledronate infusion. Symptoms escalated but ultimately resolved with topical steroids and high-dose systemic corticosteroids. To our knowledge, this is the first report of unilateral diffuse inflammation of the eye and orbit, including corneal inflammation developing within 12 hours of a first zoledronate infusion.
双膦酸盐已成为治疗骨质疏松症和其他骨病的常用药物类别。唑来膦酸盐（唑来膦酸）可通过静脉输注每年给药一次，这使其成为患者和医生的一个有吸引力的选择。我们报告了一例68岁女性的病例，她在接受首次唑来膦酸盐输注12小时后出现严重的单侧眼部炎症，包括角膜内皮炎、伴有前房积血的前葡萄膜炎、巩膜炎和眼眶炎症。症状逐渐加重，但最终通过局部类固醇和高剂量全身皮质类固醇得以缓解。据我们所知，这是首次报告在首次唑来膦酸盐输注12小时内出现包括角膜炎症在内的单侧眼部和眼眶弥漫性炎症。
