TFIIH是癌细胞新的致命弱点吗？
Is TFIIH the new Achilles heel of cancer cells?
作者信息
Berico Pietro, Coin Frédéric
机构信息
a IGBMC, Department of Functional Genomics and Cancer , CNRS/INSERM/University of Strasbourg , Strasbourg , France.
b Centre National de la Recherche Scientifique , Illkirch , France.
出版信息
Transcription. 2018;9(1):47-51. doi: 10.1080/21541264.2017.1331723. Epub 2017 Oct 4.
Abstract
TFIIH is a 10-subunit complex involved in transcription and DNA repair. It contains several enzymatic activities including a ATP-dependent DNA translocase in XPB and a cyclin-dependent kinase in CDK7. Recently the discovery of several XPB and CDK7 inhibitors with specific impact on the transcriptional addiction of many tumors pinpointed these activities as potential target in cancer chemotherapy. Unexpectedly a basal transcription factor involved in global mRNA expression now emerges a one of the most clinically promising Achilles heels of cancerous cells. These inhibitors also proved to be useful tools to unveil new functions of TFIIH in gene expression.
摘要
TFIIH是一种由10个亚基组成的复合物，参与转录和DNA修复。它具有多种酶活性，包括XPB中的ATP依赖性DNA转位酶和CDK7中的细胞周期蛋白依赖性激酶。最近，发现了几种对许多肿瘤的转录成瘾有特定影响的XPB和CDK7抑制剂，这些活性被确定为癌症化疗的潜在靶点。出乎意料的是，一个参与全局mRNA表达的基础转录因子现在成为癌细胞最具临床前景的致命弱点之一。这些抑制剂也被证明是揭示TFIIH在基因表达中新功能的有用工具。
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