He Yong, Jiang Zhenjie, Tong Fengzhi, Li Mingwu, Yin Xingru, Hu Shixin, Wang Linlin
Master, Department of Thoracic Surgery, 5th People's Hospital of Dalian, China. Conception of the study, interpretation of data, statistical analysis.
Master, Department of Thoracic Surgery, People's Hospital of Dalian, China. Acquisition of data, statistical analysis.
Acta Cir Bras. 2017 Jul;32(7):568-575. doi: 10.1590/s0102-865020170070000008.
: To evaluate the possibility of using peripheral-blood presurfactant protein B (Pro-SFTPB) for screening non-small cell lung cancer (NSCLC).
: A total of 873 healthy volunteers and 165 lung cancer patients hospitalized in the Fifth People's Hospital of Dalian were tested Pro-SFTPB once every half year from January 2014 to September 2015. The healthy volunteers were also conducted spiral computed tomography (CT) examination once every year. The data were then com-pared and statistically analyzed.
: The positive expression rate of Pro-SFTPB in NSCLC was significantly higher than that in healthy volunteers, and significantly higher in lung adenocarcinoma than in squamous cell carcinoma; additionally, the expression rate was increased with the in-crease of smoking index, and the intergroup differences showed statistical signifi-cance (p≤0.05). The positive rate of newly diagnosed lung cancer was 29.55%, higher than healthy volunteers (22.34%), but there was no significant difference (p>0.05).
: Pro-SFTPB is over expressed in non-small cell lung cancer, especially in lung adeno-carcinoma, but it can't be used as a clinical screening tool for lung cancer.
评估使用外周血表面活性蛋白B（Pro-SFTPB）筛查非小细胞肺癌（NSCLC）的可能性。
2014年1月至2015年9月期间，对873名健康志愿者和大连市第五人民医院收治的165例肺癌患者每半年检测一次Pro-SFTPB。健康志愿者每年还进行一次螺旋计算机断层扫描（CT）检查。然后对数据进行比较和统计分析。
NSCLC中Pro-SFTPB的阳性表达率显著高于健康志愿者，肺腺癌中的阳性表达率显著高于鳞状细胞癌；此外，表达率随吸烟指数的增加而升高，组间差异具有统计学意义（p≤0.05）。新诊断肺癌的阳性率为29.55%，高于健康志愿者（22.34%），但差异无统计学意义（p>0.05）。
Pro-SFTPB在非小细胞肺癌中过度表达，尤其是在肺腺癌中，但它不能用作肺癌的临床筛查工具。
