氯氰菊酯在蛋鸡体内的吸收、分布、代谢及体外消化
Absorption, Distribution, Metabolism, and in Vitro Digestion of Beta-Cypermethrin in Laying Hens.
作者信息
Liu Xueke, Wang Peng, Liu Chang, Liang Yiran, Zhou Zhiqiang, Liu Donghui
机构信息
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University , Beijing, 100193, P. R. China.
出版信息
J Agric Food Chem. 2017 Sep 6;65(35):7647-7652. doi: 10.1021/acs.jafc.7b02581. Epub 2017 Aug 21.
Beta-cypermethrin (beta-CP), an important pyrethroid insecticide, and its main acid metabolites are frequently detected in human samples. Because beta-CP may pose some risk to human health, we studied dynamics and residues of beta-CP and its metabolites in hen egg, droppings, blood, and 15 other tissues after continuous exposure. A digestive model was then used to study beta-CP's digestive fate. Beta-CP and its metabolites significantly accumulated in tissues with high lipid contents and were readily transferred to eggs. Beta-CP was mainly metabolized into acid metabolites that accumulated in egg and edible tissues of laying hens, suggesting that humans may be exposed to beta-CP acid metabolites through food.
高效氯氰菊酯（β-氯氰菊酯，beta-CP）是一种重要的拟除虫菊酯类杀虫剂，其主要酸性代谢产物经常在人体样本中被检测到。由于β-氯氰菊酯可能对人体健康构成一定风险，我们研究了连续暴露后β-氯氰菊酯及其代谢产物在鸡蛋、粪便、血液以及其他15种组织中的动态变化和残留情况。随后使用一个消化模型来研究β-氯氰菊酯的消化归宿。β-氯氰菊酯及其代谢产物在高脂含量的组织中显著蓄积，并易于转移至鸡蛋中。β-氯氰菊酯主要代谢为酸性代谢产物，这些产物在蛋鸡的鸡蛋和可食用组织中蓄积，这表明人类可能通过食物接触到β-氯氰菊酯酸性代谢产物。
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