Liu Xueke, Wang Peng, Liu Chang, Liang Yiran, Zhou Zhiqiang, Liu Donghui
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University , Beijing, 100193, P. R. China.
J Agric Food Chem. 2017 Sep 6;65(35):7647-7652. doi: 10.1021/acs.jafc.7b02581. Epub 2017 Aug 21.
Beta-cypermethrin (beta-CP), an important pyrethroid insecticide, and its main acid metabolites are frequently detected in human samples. Because beta-CP may pose some risk to human health, we studied dynamics and residues of beta-CP and its metabolites in hen egg, droppings, blood, and 15 other tissues after continuous exposure. A digestive model was then used to study beta-CP's digestive fate. Beta-CP and its metabolites significantly accumulated in tissues with high lipid contents and were readily transferred to eggs. Beta-CP was mainly metabolized into acid metabolites that accumulated in egg and edible tissues of laying hens, suggesting that humans may be exposed to beta-CP acid metabolites through food.
高效氯氰菊酯（β-氯氰菊酯，beta-CP）是一种重要的拟除虫菊酯类杀虫剂，其主要酸性代谢产物经常在人体样本中被检测到。由于β-氯氰菊酯可能对人体健康构成一定风险，我们研究了连续暴露后β-氯氰菊酯及其代谢产物在鸡蛋、粪便、血液以及其他15种组织中的动态变化和残留情况。随后使用一个消化模型来研究β-氯氰菊酯的消化归宿。β-氯氰菊酯及其代谢产物在高脂含量的组织中显著蓄积，并易于转移至鸡蛋中。β-氯氰菊酯主要代谢为酸性代谢产物，这些产物在蛋鸡的鸡蛋和可食用组织中蓄积，这表明人类可能通过食物接触到β-氯氰菊酯酸性代谢产物。
