Grimm R H
Am J Med. 1987 Jan 5;82(1A):26-30. doi: 10.1016/0002-9343(87)90140-9.
The results of several important clinical trials have confirmed the benefits of pharmacologic treatment in patients with hypertension. However, some issues concerning this type of treatment have yet to be resolved. For example, it has not been determined whether there are differences among antihypertensive agents with respect to their effects on mortality and morbidity or whether such effects are independent of the alterations in blood pressure resulting from the use of such agents. Thiazide diuretics, the most commonly prescribed antihypertensive drugs, were the first agents proven to be effective and practical for the widespread treatment of hypertension. Alpha blockers, also commonly prescribed antihypertensive drugs, provide equally effective blood pressure control to that of the thiazides, but with a very different metabolic profile. In this article, these drugs are compared for efficacy, side-effect profiles, metabolic effects, and potential for reducing the risk of coronary heart disease.
几项重要临床试验的结果证实了药物治疗对高血压患者的益处。然而，这类治疗的一些问题尚未得到解决。例如，尚未确定抗高血压药物在对死亡率和发病率的影响方面是否存在差异，或者这些影响是否独立于使用此类药物导致的血压变化。噻嗪类利尿剂是最常用的抗高血压药物，是首批被证明对广泛治疗高血压有效且实用的药物。α受体阻滞剂也是常用的抗高血压药物，能提供与噻嗪类药物同样有效的血压控制，但代谢情况却大不相同。在本文中，将对这些药物在疗效、副作用、代谢影响以及降低冠心病风险的潜力方面进行比较。
