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miR-290-295簇在小鼠胚胎干细胞中扮演多面角色。

The miR-290-295 cluster as multi-faceted players in mouse embryonic stem cells.

作者信息

Yuan Kai, Ai Wen-Bing, Wan Lin-Yan, Tan Xiao, Wu Jiang-Feng

机构信息

Institute of Organ Fibrosis and Targeted Drug Delivery, Medical College, China Three Gorges University, 8 Daxue Road, Xiling District, Yichang, 443002 China.

The Yiling Hospital of Yichang, 31 Donghu Road, Yi Ling District, Yichang, 443100 Hubei China.

出版信息

Cell Biosci. 2017 Aug 7;7:38. doi: 10.1186/s13578-017-0166-2. eCollection 2017.

DOI:10.1186/s13578-017-0166-2
PMID:28794853
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5547456/
Abstract

Increasing evidence indicates that embryonic stem cell specific microRNAs (miRNAs) play an essential role in the early development of embryo. Among them, the miR-290-295 cluster is the most highly expressed in the mouse embryonic stem cells and involved in various biological processes. In this paper, we reviewed the research progress of the function of the miR-290-295 cluster in embryonic stem cells. The miR-290-295 cluster is involved in regulating embryonic stem cell pluripotency maintenance, self-renewal, and reprogramming somatic cells to an embryonic stem cell-like state. Moreover, the miR-290-295 cluster has a latent pro-survival function in embryonic stem cells and involved in tumourigenesis and senescence with a great significance. Elucidating the interaction between the miR-290-295 cluster and other modes of gene regulation will provide us new ideas on the biology of pluripotent stem cells. In the near future, the broad prospects of the miRNA cluster will be shown in the stem cell field, such as altering cell identities with high efficiency through the transient introduction of tissue-specific miRNA cluster.

摘要

越来越多的证据表明，胚胎干细胞特异性微小RNA（miRNA）在胚胎早期发育中起着至关重要的作用。其中，miR-290-295簇在小鼠胚胎干细胞中表达最为丰富，并参与多种生物学过程。在本文中，我们综述了miR-290-295簇在胚胎干细胞中功能的研究进展。miR-290-295簇参与调节胚胎干细胞多能性的维持、自我更新以及将体细胞重编程为胚胎干细胞样状态。此外，miR-290-295簇在胚胎干细胞中具有潜在的促生存功能，并在肿瘤发生和衰老过程中具有重要意义。阐明miR-290-295簇与其他基因调控模式之间的相互作用将为我们提供关于多能干细胞生物学的新思路。在不久的将来，miRNA簇在干细胞领域将展现广阔的前景，例如通过短暂引入组织特异性miRNA簇高效改变细胞特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/481aa11fbee3/13578_2017_166_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/0ba564744d1a/13578_2017_166_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/a04f9a9ba5b5/13578_2017_166_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/972623121571/13578_2017_166_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/fc72004114f7/13578_2017_166_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/c9c4b378d6aa/13578_2017_166_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/c9682b85891b/13578_2017_166_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/481aa11fbee3/13578_2017_166_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/0ba564744d1a/13578_2017_166_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/406ddeac2710/13578_2017_166_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/a04f9a9ba5b5/13578_2017_166_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/972623121571/13578_2017_166_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/fc72004114f7/13578_2017_166_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/c9c4b378d6aa/13578_2017_166_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/c9682b85891b/13578_2017_166_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/728c/5547456/481aa11fbee3/13578_2017_166_Fig8_HTML.jpg

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