Orofino Nicola, Cattaneo Daniele, Bucelli Cristina, Pettine Loredana, Fabris Sonia, Gianelli Umberto, Fracchiolla Nicola Stefano, Cortelezzi Agostino, Iurlo Alessandra
Hematology Division, IRCCS Ca' Granda - Maggiore Policlinico Hospital Foundation, Milan, Italy.
Division of Pathology, Department of Pathophysiology and Transplantation, University of Milan, and IRCCS Ca' Granda - Maggiore Policlinico Hospital Foundation, Milan, Italy.
Leuk Res Rep. 2017 Jul 27;8:7-10. doi: 10.1016/j.lrr.2017.07.002. eCollection 2017.
Myeloid Sarcoma (MS) is a rare malignancy that can present as an isolated disease or more frequently in association with or following acute myeloid leukemia or other myeloid neoplasms and rarely following myelofibrosis. Since molecular pathogenesis and prognostic factors of MS are not well understood, its prognosis remains poor even in the era of novel agents and target therapies. We report the case of a patient with MS following myelofibrosis with multiple subcutaneous, cutaneous and muscle localizations; the latter has been reported in the literature as anecdotal. In this way we aimed to enhance the understanding of this disease.
髓系肉瘤(MS)是一种罕见的恶性肿瘤,可表现为孤立性疾病,或更常见地与急性髓系白血病或其他髓系肿瘤相关或继发于这些疾病之后,很少继发于骨髓纤维化之后。由于MS的分子发病机制和预后因素尚未完全明确,即使在新型药物和靶向治疗时代,其预后仍然较差。我们报告了一例骨髓纤维化后发生的MS患者,该患者有多处皮下、皮肤和肌肉定位;后者在文献中仅有个案报道。通过这种方式,我们旨在加深对这种疾病的认识。