Nunes Laiz Fernandes Mendes, Rocha Amanda Leal, Magalhães Gustavo Henrique Romani, de Melo Frederico Henrique Corrêa, Travassos Denise Vieira, Mesquita Ricardo Alves, Silva Tarcília Aparecida
Dental Surgeon Resident, Hospital das Clinicas, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
Department of Oral Surgery and Pathology, Faculty of Dentistry, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
Spec Care Dentist. 2018 Nov;38(6):409-420. doi: 10.1111/scd.12325. Epub 2018 Sep 6.
Granulocytic sarcoma (GS) is an extramedullary tumor associated with myelodysplastic syndromes or myeloproliferative diseases. Intraoral manifestations are considered uncommon, with a reasonable number of cases, and are mostly related to leukemia. The association of oral GS and myelofibrosis is very rare and only three cases have been published. In this paper, we report the fourth case of oral lesion in a patient with a diagnosis of myelofibrosis. The aim of this study was to present a review of the literature, discussing the current and previous cases of oral GS associated with myelofibrosis or other hematological disorders and the importance of accurate diagnosis through clinical, microscopic, and immunohistochemical features.
粒细胞肉瘤(GS)是一种与骨髓增生异常综合征或骨髓增殖性疾病相关的髓外肿瘤。口腔表现被认为不常见,病例数量有限,且大多与白血病有关。口腔GS与骨髓纤维化的关联非常罕见,仅有3例报道。本文报告了第4例诊断为骨髓纤维化患者的口腔病变。本研究的目的是对文献进行综述,讨论目前及既往口腔GS与骨髓纤维化或其他血液系统疾病相关的病例,以及通过临床、显微镜和免疫组化特征进行准确诊断的重要性。