断奶前肾上腺切除术以及短期或长期给予糖皮质激素对遗传性肥胖 Zucker 大鼠的影响。
Effects of adrenalectomy before weaning and short- or long-term glucocorticoid administration on the genetically obese Zucker rat.
作者信息
Fletcher J M
出版信息
Biochem J. 1986 Sep 1;238(2):459-63. doi: 10.1042/bj2380459.
Abstract
Intact obese rats were hyperinsulinaemic, had higher rates of whole-body fatty acid synthesis, higher activities of hepatic acetyl-CoA carboxylase and tyrosine aminotransferase and a higher hepatic glycogen concentration than intact lean animals. Adrenalectomy abolished all these factors of the obese phenotype. Treatment of adrenalectomized rats with corticosterone for 24 h increased the rate of whole-body fatty acid synthesis to the same extent in both phenotypes, but caused a larger increase in glycogen concentration, tyrosine aminotransferase activity and plasma insulin concentration in obese rats.
摘要
完整的肥胖大鼠存在高胰岛素血症，其全身脂肪酸合成速率更高，肝脏乙酰辅酶A羧化酶和酪氨酸转氨酶活性更高，肝脏糖原浓度也高于完整的瘦动物。肾上腺切除术消除了肥胖表型的所有这些因素。用皮质酮对肾上腺切除的大鼠进行24小时治疗，两种表型的全身脂肪酸合成速率均增加到相同程度，但肥胖大鼠的糖原浓度、酪氨酸转氨酶活性和血浆胰岛素浓度升高幅度更大。
相似文献
1
Effects of adrenalectomy before weaning and short- or long-term glucocorticoid administration on the genetically obese Zucker rat.断奶前肾上腺切除术以及短期或长期给予糖皮质激素对遗传性肥胖 Zucker 大鼠的影响。
Biochem J. 1986 Sep 1;238(2):459-63. doi: 10.1042/bj2380459.
2
Effects of adrenalectomy before weaning in the genetically obese Zucker rat (fa/fa).
Br J Nutr. 1986 Jul;56(1):141-51. doi: 10.1079/bjn19860094.
3
The parasympathetic nervous system and glucocorticoid-mediated hyperinsulinaemia in the genetically obese (fa/fa) Zucker rat.遗传性肥胖（fa/fa） Zucker大鼠的副交感神经系统与糖皮质激素介导的高胰岛素血症
J Endocrinol. 1988 Jul;118(1):87-92. doi: 10.1677/joe.0.1180087.
4
Regulation of hepatic tyrosine aminotransferase in genetically obese rats.遗传性肥胖大鼠肝脏酪氨酸转氨酶的调节
Biochim Biophys Acta. 1983 Apr 20;756(3):297-307. doi: 10.1016/0304-4165(83)90338-0.
5
The postprandial rates of glycogen and lipid synthesis of lean and obese female Zucker rats.瘦型和肥胖型雌性 Zucker 大鼠餐后糖原和脂质合成率
Int J Obes Relat Metab Disord. 2000 Apr;24(4):508-13. doi: 10.1038/sj.ijo.0801189.
6
The effects of dietary fat content on the growth and body composition of lean and genetically obese Zucker rats adrenalectomized before weaning.断奶前肾上腺切除的瘦型和遗传性肥胖 Zucker 大鼠的膳食脂肪含量对其生长和身体组成的影响。
Br J Nutr. 1988 Nov;60(3):563-9. doi: 10.1079/bjn19880128.
7
Improved metabolic status and insulin sensitivity in obese fatty (fa/fa) Zucker rats and Zucker Diabetic Fatty (ZDF) rats treated with the thiazolidinedione, MCC-555.噻唑烷二酮类药物MCC - 555治疗肥胖型脂肪（fa/fa） Zucker大鼠和Zucker糖尿病脂肪（ZDF）大鼠可改善其代谢状态和胰岛素敏感性。
Br J Pharmacol. 1998 Dec;125(8):1708-14. doi: 10.1038/sj.bjp.0702245.
8
Comparative studies on fatty acid synthesis, glycogen metabolism, and gluconeogenesis by hepatocytes isolated from lean and obese Zucker rats.对从瘦型和肥胖型 Zucker 大鼠分离的肝细胞进行脂肪酸合成、糖原代谢和糖异生的比较研究。
Metabolism. 1981 Dec;30(12):1170-8. doi: 10.1016/0026-0495(81)90037-8.
9
Differences in binding of hepatic nuclear proteins from lean and obese rats to the 5'-upstream region of tyrosine aminotransferase.lean和肥胖大鼠肝细胞核蛋白与酪氨酸转氨酶5'-上游区域结合的差异。
Obes Res. 1997 May;5(3):208-17. doi: 10.1002/j.1550-8528.1997.tb00295.x.
10
Metabolic measurements among homozygous (fa/fa) obese, heterozygous (Fa/fa) lean and homozygous (Fa/Fa) lean Zucker rat pups at 17 days of age.17日龄的纯合子（fa/fa）肥胖、杂合子（Fa/fa）瘦型和纯合子（Fa/Fa）瘦型 Zucker 大鼠幼崽的代谢测量。
J Nutr. 1994 Aug;124(8):1230-7. doi: 10.1093/jn/124.8.1230.
引用本文的文献
1
Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice.无肥胖的代谢综合征：11β-羟基类固醇脱氢酶1型在转基因小鼠肝脏中的过表达
Proc Natl Acad Sci U S A. 2004 May 4;101(18):7088-93. doi: 10.1073/pnas.0305524101. Epub 2004 Apr 26.
2
Effect of adrenalectomy on the development of a pancreatic islet lesion in fa/fa rats.肾上腺切除术对fa/fa大鼠胰岛病变发展的影响。
Diabetologia. 1996 Feb;39(2):190-8. doi: 10.1007/BF00403962.
本文引用的文献
1
Use of glucose oxidase, peroxidase, and O-dianisidine in determination of blood and urinary glucose.葡萄糖氧化酶、过氧化物酶和邻联茴香胺在血液及尿液葡萄糖测定中的应用
Lancet. 1957 Aug 24;273(6991):368-70. doi: 10.1016/s0140-6736(57)92595-3.
2
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
3
Development of obesity in Zucker obese (fafa) rat in absence of hyperphagia.在无食欲亢进情况下，Zucker肥胖（fafa）大鼠肥胖症的发展。
Am J Physiol. 1980 Mar;238(3):E284-92. doi: 10.1152/ajpendo.1980.238.3.E284.
4
Fatty acid synthesis in vivo and hepatic contribution to whole-body lipogenic rates in obese Zucker rats.
Lipids. 1980 Dec;15(12):993-8. doi: 10.1007/BF02534313.
5
The effect of adrenalectomy on GDP binding to brown-adipose-tissue mitochondria of obese rat.肾上腺切除术对肥胖大鼠棕色脂肪组织线粒体中GDP结合的影响。
Biochem J. 1982 Dec 15;208(3):819-22. doi: 10.1042/bj2080819.
6
Radioimmunoassay (RIA) of serum corticosterone in rats.大鼠血清皮质酮的放射免疫分析
Proc Soc Exp Biol Med. 1982 May;170(1):29-34. doi: 10.3181/00379727-170-41391.
7
Development of pancreatic and plasma insulin in prenatal and suckling Zucker rats.产前和哺乳期Zucker大鼠胰腺及血浆胰岛素的发育情况
Am J Physiol. 1982 Apr;242(4):E220-5. doi: 10.1152/ajpendo.1982.242.4.E220.
8
9
Adrenalectomy and food restriction in the genetically obese (ob/ob) mouse.基因肥胖（ob/ob）小鼠的肾上腺切除术与食物限制
Am J Physiol. 1984 Jan;246(1 Pt 2):R20-5. doi: 10.1152/ajpregu.1984.246.1.R20.
10
Regulation of hepatic tyrosine aminotransferase in genetically obese rats.遗传性肥胖大鼠肝脏酪氨酸转氨酶的调节
Biochim Biophys Acta. 1983 Apr 20;756(3):297-307. doi: 10.1016/0304-4165(83)90338-0.
Zotero 插件