GIGA - In Silico Medicine, University of Liege, Liege, Belgium.
GIGA - Cardiovascular Sciences, University of Liege, Liege, Belgium.
Med Biol Eng Comput. 2018 Mar;56(3):421-434. doi: 10.1007/s11517-017-1694-y. Epub 2017 Aug 9.
The extracorporeal CO removal device (ECCORD) is used in clinics to treat patients suffering from respiratory failures like acute respiratory distress syndrome (ARDS) or chronic obstructive pulmonary disease (COPD). The aim of this device is to decarboxylate blood externally with low blood flow. A mathematical model is proposed to describe protective ventilation, ARDS, and an extracorporeal CO removal therapy (ECCORT). The simulations are compared with experimental data carried out on ten pigs. The results show a good agreement between the mathematical simulations and the experimental data, which provides a nice validation of the model. This model is thus able to predict the decrease of PCO during ECCORT for different blood flows across the extracorporeal lung support.
体外 CO 去除设备 (ECCORD) 用于治疗患有呼吸衰竭的患者，如急性呼吸窘迫综合征 (ARDS) 或慢性阻塞性肺疾病 (COPD)。该设备的目的是在外周低血流量下脱除血液中的 CO。提出了一个数学模型来描述保护性通气、ARDS 和体外 CO 去除治疗 (ECCORT)。模拟结果与在 10 头猪上进行的实验数据进行了比较。结果表明，数学模拟与实验数据之间具有良好的一致性，这为模型提供了很好的验证。因此，该模型能够预测在不同的体外肺支持血流下进行 ECCORT 时 PCO 的降低。
