Relling M V, Krauss R M, Roden D M, Klein T E, Fowler D M, Terada N, Lin L, Riel-Mehan M, Do T P, Kubo M, Yee S W, Johnson G T, Giacomini K M
Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
Children's Hospital Oakland Research Institute, Oakland, California, USA.
Clin Pharmacol Ther. 2017 Dec;102(6):897-902. doi: 10.1002/cpt.755. Epub 2017 Aug 10.
The goal of pharmacogenomics research is to discover genetic polymorphisms that underlie variation in drug response. Increasingly, pharmacogenomics research involves large numbers of patients and the application of new technologies and methodologies to enable discovery. The Pharmacogenomics Research Network (PGRN) has become a community-driven network of investigators spanning scientific and clinical disciplines. Here, we highlight the activities and types of resources that enable PGRN members to enhance and drive basic and translational research in pharmacogenomics.
药物基因组学研究的目标是发现构成药物反应差异基础的基因多态性。药物基因组学研究越来越多地涉及大量患者,并应用新技术和方法来实现发现。药物基因组学研究网络(PGRN)已成为一个由社区驱动的、涵盖科学和临床学科的研究人员网络。在这里,我们重点介绍使PGRN成员能够加强和推动药物基因组学基础研究与转化研究的活动和资源类型。