药物基因组学——我们距离为儿童实施个性化医疗还有多远/近？
Pharmacogenomics--how close/far are we to practising individualized medicine for children?
作者信息
Sing Chor-Wing, Cheung Ching-Lung, Wong Ian C K
出版信息
Br J Clin Pharmacol. 2015 Mar;79(3):419-28. doi: 10.1111/bcp.12338.
Abstract
The translation of pharmacogenomics into clinical practice is a key approach for practising individualized medicine, which aims to maximize drug efficacy and minimize drug toxicity. Since the completion of both the Human Genome Project and the International HapMap project, the development of pharmacogenomics has been greatly facilitated. However, progress in translating pharmacogenomics into clinical practice, especially in paediatric medicine, is unexpectedly slow. Many challenges from different areas remain. This paper discusses the existing applications and the limitations to the implementation of paediatric pharmacogenomics, as well as possible solutions for overcoming these limitations and challenges.
摘要
药物基因组学转化为临床实践是实施个体化医疗的关键途径，其目的是使药物疗效最大化并使药物毒性最小化。自人类基因组计划和国际人类基因组单体型图计划完成以来，药物基因组学的发展得到了极大推动。然而，药物基因组学转化为临床实践的进程，尤其是在儿科医学领域，却出人意料地缓慢。来自不同领域的诸多挑战依然存在。本文讨论了儿科药物基因组学的现有应用及其实施过程中的局限性，以及克服这些局限性和挑战的可能解决方案。
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