Wu Wei, Chen Anting, Tong Linyue, Qing Ziqi, Langone Kevin P, Bernier William E, Jones Wayne E
Department of Chemistry, State University of New York at Binghamton , Binghamton, New York 13902-6016, United States.
ACS Sens. 2017 Sep 22;2(9):1337-1344. doi: 10.1021/acssensors.7b00400. Epub 2017 Aug 23.
Fluorescent conjugated polyelectrolytes represent an exciting area of research into new chemosensors. By virtue of their rapid electron and energy transfer paths, these highly correlated, one-dimensional systems have been depicted as "molecular wires" and show "million-fold" sensitivity compared to monomolecular sensor analogs. In this paper, a novel polyelectrolyte sensor, the ttp-PPESO, has been designed by incorporating terpyridine and sulfonate functional groups into the polyelectrolyte. This specifically tailored sensor has displayed remarkable quenching response toward copper(II) with a detection limit of 14.7 nM (0.93 ppb). It is capable of selectively screening copper without interference from 12 common cations. Molecular modeling suggests that binding occurs through a coordination interaction of the terpyridine and sulfonate. The additional multidentate nature from the sulfonate offers extraordinary chelating ability to the analyte. We anticipate that this unique binding mode will provide insight for the design of future more sensitive and selective systems.
荧光共轭聚电解质是新型化学传感器研究中一个令人兴奋的领域。凭借其快速的电子和能量转移路径，这些高度相关的一维体系被描绘为“分子导线”，与单分子传感器类似物相比显示出“百万倍”的灵敏度。在本文中，通过将三联吡啶和磺酸酯官能团引入聚电解质中，设计了一种新型聚电解质传感器ttp-PPESO。这种经过特殊定制的传感器对铜（II）表现出显著的猝灭响应，检测限为14.7 nM（0.93 ppb）。它能够选择性地筛选铜，不受12种常见阳离子的干扰。分子模拟表明，结合是通过三联吡啶和磺酸酯的配位相互作用发生的。磺酸酯额外的多齿性质为分析物提供了非凡的螯合能力。我们预计这种独特的结合模式将为未来设计更灵敏和选择性更高的体系提供思路。
