Chemistry Department, Faculty of Art and Science, Eastern Mediterranean University, TR.North Cyprus via Mersin 10, Gazimagusa, Turkey.
Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Eastern Mediterranean University, TR.North Cyprus via Mersin 10, Gazimagusa, Turkey.
J Fluoresc. 2020 Jan;30(1):113-120. doi: 10.1007/s10895-019-02475-0. Epub 2020 Jan 2.
The detection and sensing of environmentally crucial metal ions has always been of great significance in various fields such as biological and environmental cycles. Our previous studies have indicated a new coumarin based lactone, Urolithin B (i.e., 3-Hydroxy[c]chromen-6-one) as a potent fluorescent probe for the selective detection of Iron (III). In order to question the extension of this application to other urolithins, we have synthesized the major urolithins that humans are exposed to through regular diet. Following the structure identifying studies, the compounds were tested in fluorescence titration to investigate their interaction with various metals. The results have indicated that each title compound is selective to interact with Iron (III) in ON-OFF mode, independent from the presence of another metal. Similar to the previous findings, the Job's plots displaying the ratio of complex formation 3:2 UROs:Fe have indicated the significance of the lactone group solely.
环境中关键金属离子的检测和传感在生物和环境循环等各个领域一直具有重要意义。我们之前的研究表明，新型香豆素内酯尿石素 B（即 3-羟基[c]色满-6-酮）可用作铁（III）选择性荧光探针。为了探讨这种应用是否可以扩展到其他尿石素，我们已经合成了人类通过日常饮食摄入的主要尿石素。在结构鉴定研究之后，对化合物进行荧光滴定实验以研究它们与各种金属的相互作用。结果表明，标题化合物均以 ON-OFF 模式选择性地与铁（III）相互作用，而不受其他金属的存在影响。与之前的发现相似，显示配合物形成 3:2 UROs:Fe 比例的 Job 图表明仅内酯基团具有重要意义。
