a Research Center for Immunodeficiencies, Children's Medical Center , Tehran University of Medical Sciences , Tehran , Iran.
b Department of Endodontics, Dental Branch , Tehran Azad University , Tehran , Iran.
Expert Rev Clin Immunol. 2017 Oct;13(10):1001-1015. doi: 10.1080/1744666X.2017.1366315. Epub 2017 Aug 23.
Cancer immunotherapy has evolved and is aimed at generating the efficacious therapeutic modality to enhance the specificity and power of the immune system to combat tumors. Areas covered: Current efforts in cancer immunotherapy fall into three main approaches. One approach is through the blockade of immune checkpoints, another approach is through adoptive cellular therapy, and the last approach is through vaccination. The goal of this review is to summarize the current understanding and status of cancer immunotherapy in these three categories. Expert commentary: We foresee the development of therapeutic protocols combining these approaches with each other or conventional therapies to achieve the most appropriate guideline for management of cancer.
癌症免疫疗法已经发展，旨在产生有效的治疗方式，以提高免疫系统对抗肿瘤的特异性和效力。
目前癌症免疫疗法的努力分为三种主要方法。一种方法是通过阻断免疫检查点，另一种方法是通过过继性细胞疗法，最后一种方法是通过疫苗接种。本综述的目的是总结这三种方法中癌症免疫疗法的当前理解和现状。
我们预计将这些方法与常规疗法相结合或联合常规疗法开发治疗方案，以制定最适合癌症管理的指南。
