Division of Rheumatology, University of Pavia, IRCCS Policlinico S. Matteo Foundation, Pavia, Italy.
Curr Opin Rheumatol. 2017 Nov;29(6):612-617. doi: 10.1097/BOR.0000000000000434.
To provide the most recent evidence on anti-Jo-1 syndrome.
Several new evidences on anti-Jo-1 syndrome have recently emerged. It has been clearly established that, at disease onset, the classic clinical triad (arthritis, myositis and interstitial lung disease - ILD) is only rarely observed. Indeed, disease onset with an isolated arthritis is common. Patients presenting with an isolated manifestation are at high risk for the subsequent occurrence of initially lacking triad findings. Moreover, the ex-novo occurrence of accompanying features such as Raynaud's phenomenon, mechanic's hands and fever during follow-up is a strong risk factor for the occurrence of overt antisynthetase syndrome (ASSD) with further triad manifestations. Several contributions on ILD involvement and prognosis have been published, as well as the distinctive muscle MRI characteristics compared with healthy controls, and a novel definition of a rare skin manifestation (hiker's feet).
Recent evidence has shed a light on the need for a better understanding of the clinical course, imaging modalities and prognosis of anti-Jo-1 syndrome, providing some relevant elements to allow early diagnosis of this often unrecognized disease.
提供抗 Jo-1 综合征的最新证据。
抗 Jo-1 综合征最近出现了一些新的证据。已经明确的是，在疾病发作时，经典的三联征（关节炎、肌炎和间质性肺病 -ILD）很少出现。事实上，关节炎首发且孤立存在很常见。出现孤立表现的患者随后出现最初三联征缺失的风险很高。此外，在随访过程中雷诺现象、机械手和发热等伴随特征的新出现是出现明显抗合成酶综合征（ASSD）和进一步三联征表现的强烈危险因素。已经发表了一些关于ILD 受累和预后的研究，以及与健康对照组相比独特的肌肉 MRI 特征，以及一种罕见皮肤表现（徒步旅行者的脚）的新定义。
最近的证据表明需要更好地了解抗 Jo-1 综合征的临床过程、影像学模式和预后，为早期诊断这一经常未被识别的疾病提供了一些相关要素。
