Mielnik Pawel, Wiesik-Szewczyk Ewa, Olesinska Marzena, Chwalinska-Sadowska Hanna, Zabek Jakub
Institute of Rheumatology, Department of Connective Tissue Diseases, Warsaw, Poland.
Autoimmunity. 2006 May;39(3):243-7. doi: 10.1080/08916930600623767.
The idiopathic inflammatory myopathies are a heterogeneous group of diseases that can involve various systems. Antibodies directed against aminoacyl-tRNA synthetases, such as anti-Jo-1 antibodies, are strongly associated with a syndrome which consists of myositis, interstitial lung disease (ILD), arthritis and Raynaud's phenomenon. Forty-one patients with various forms of idiopathic inflammatory myopathies were assessed: 14 patients with anti-Jo-1 antibodies and 27 patients without anti-Jo-1 antibodies as a control group. We retrospectively analysed clinical symptoms, treatment and outcome in both groups. Patients with anti-Jo-1 antibodies more often had ILD (64.2 vs. 11.1%), arthritis (64.2 vs. 18.1%) and Raynaud's phenomenon (38 vs. 0%). Patients without the anti-Jo-1 antibody presented worse muscle strength and more frequently myalgia (37 vs. 21%), cutaneous rash (18.5 vs. 7%), heliotrope rash (29% vs. 7%) and periungueal changes (22 vs. 0%) than the anti-Jo-1-positive patients. Outcome was good in both groups. Improvement was achieved in the 14 (100%) Jo-1 positive patients, and in 25 (92.5%) controls. Two (7.5%) patients from control group achieved remission.
特发性炎性肌病是一组异质性疾病，可累及多个系统。针对氨酰 - tRNA合成酶的抗体，如抗Jo - 1抗体，与一种综合征密切相关，该综合征包括肌炎、间质性肺疾病（ILD）、关节炎和雷诺现象。对41例各种形式的特发性炎性肌病患者进行了评估：14例抗Jo - 1抗体阳性患者和27例无抗Jo - 1抗体的患者作为对照组。我们回顾性分析了两组患者的临床症状、治疗及预后情况。抗Jo - 1抗体阳性患者更常出现ILD（64.2% 对11.1%）、关节炎（64.2% 对18.1%）和雷诺现象（38% 对0%）。无抗Jo - 1抗体的患者比抗Jo - 1抗体阳性患者表现出更差的肌肉力量，更频繁出现肌痛（37% 对21%）、皮疹（18.5% 对7%）、向阳疹（29% 对7%）和甲周改变（22% 对0%）。两组预后均良好。14例（100%）抗Jo - 1抗体阳性患者病情改善，25例（92.5%）对照组患者病情改善。对照组中有2例（7.5%）患者病情缓解。
