Alam Parvej, Leung Nelson L C, Su Huifang, Qiu Zijie, Kwok Ryan T K, Lam Jacky W Y, Tang Ben Zhong
HKUST Shenzhen Research Institute, No. 9 Yuexing 1st Rd, South Area, Hi-tech Park, Nanshan, Shenzhen, 518057, P. R. China.
Department of Chemistry, Division of Biomedical Engineering, Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction, Institute for Advanced Study, Institute of Molecular Functional Materials and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, P. R. China.
Chemistry. 2017 Oct 20;23(59):14911-14917. doi: 10.1002/chem.201703253. Epub 2017 Sep 25.
The detection of food spoilage is a major concern in food safety as large amounts of food are transported globally. Direct analysis of food samples is often time-consuming and requires expensive analytical instrumentation. A much simpler and more cost-effective method for monitoring food fermentation is to detect biogenic amines generated as a by-product during food decomposition. In this work, a series of 1,2-dihydroquinoxaline derivatives (DQs) with aggregation-induced emission (AIE) characteristics were synthesised and their protonated forms, that is, H DQs, can be utilised for the sensitive detection of biogenic amines. For example, upon exposure to amine vapours, deprotonation occurs that converts the red-coloured, non-emissive H DQ2 back to its yellow-coloured, fluorescent parent form. The bimodal absorption and emission changes endow the system with high sensitivity, capable of detecting ammonia vapour at a concentration of as low as 690 ppb. Taking advantage of this, H DQ2 was successfully applied for the detection of food spoilage and was established as a robust and cost effective technique to monitor food safety.
由于大量食品在全球范围内运输，食品变质的检测是食品安全领域的一个主要问题。直接分析食品样本往往耗时且需要昂贵的分析仪器。一种更简单且更具成本效益的监测食品发酵的方法是检测食品分解过程中作为副产物产生的生物胺。在这项工作中，合成了一系列具有聚集诱导发光（AIE）特性的1,2-二氢喹喔啉衍生物（DQs），其质子化形式即H-DQs可用于生物胺的灵敏检测。例如，暴露于胺蒸气时，会发生去质子化反应，使红色、不发光的H-DQ2变回其黄色、荧光的母体形式。双峰吸收和发射变化赋予该系统高灵敏度，能够检测低至690 ppb浓度的氨蒸气。利用这一点，H-DQ2成功应用于食品变质检测，并被确立为一种监测食品安全的可靠且经济高效的技术。
