De Risi Marco, Di Gennaro Giancarlo, Picardi Angelo, Casciato Sara, Grammaldo Liliana G, D'Aniello Alfredo, Lanni Deborah, Meletti Stefano, Modugno Nicola
a I.R.C.C.S. Neuromed , Pozzilli (IS) , Italy.
b Mental Health Unit, National Centre of Epidemiology, Surveillance and Health Promotion , Italian National Institute of Health , Rome , Italy.
Int J Neurosci. 2018 Jan;128(1):71-78. doi: 10.1080/00207454.2017.1366475. Epub 2017 Aug 28.
In line with the growing attention on non-motor symptoms and disturbance of affective and emotional processing in Parkinson's disease, we aimed to study the different aspects of facial emotion expression evaluation in a group of Parkinson's disease without cognitive decline in treatment with common antiparkinsonian drugs, matched for sex, age and education with healthy subjects.
The study was conducted on 30 patients (13 male; mean age: 63.3 ± 6.7; mean age of disease onset: 56.5 ± 7.1; mean duration of the disease: 6.7 ± 2.6) with a diagnosis of Parkinson's disease and receiving dopaminergic therapy, as compared with 30 healthy controls. Different tasks of facial expression evaluation were used. All patients were assessed for neuropsychological and psychological profiles during optimized medication-on condition.
The total number of errors in facial emotion recognition task is higher (p < 0.001) in patients than controls and it is due to errors in identifying sadness (p < 0.001), anger (p = 0.01) and fear (p < 0.001). No differences in the total amount of activation, valence and intensity ratings were found. The difference between patients and controls in emotion recognition appears to be independent by the severity of depressive symptoms.
The present study provides further evidence of altered non-verbal emotional information processing in Parkinson's disease patients, suggesting that nigrostriatal dopaminergic depletion leads also to emotional information processing dysfunction. The consequences of these emotional encoding disturbances in daily living and their relationship to mood and behavioural disorders remain to be clarified.
随着对帕金森病非运动症状以及情感和情绪加工障碍的关注度不断提高，我们旨在研究一组接受常用抗帕金森病药物治疗且无认知功能减退的帕金森病患者面部情绪表达评估的不同方面，这些患者在性别、年龄和教育程度上与健康受试者相匹配。
该研究对30例诊断为帕金森病且正在接受多巴胺能治疗的患者（13例男性；平均年龄：63.3±6.7岁；平均发病年龄：56.5±7.1岁；平均病程：6.7±2.6年）与30例健康对照进行。采用了不同的面部表情评估任务。所有患者在药物优化治疗状态下接受神经心理学和心理状况评估。
患者在面部情绪识别任务中的错误总数高于对照组（p<0.001），这是由于识别悲伤（p<0.001）、愤怒（p=0.01）和恐惧（p<0.001）时出现错误所致。在激活总量、效价和强度评分方面未发现差异。患者与对照组在情绪识别上的差异似乎与抑郁症状的严重程度无关。
本研究进一步证明帕金森病患者存在非言语情绪信息加工改变，提示黑质纹状体多巴胺能耗竭也导致情绪信息加工功能障碍。这些情绪编码障碍在日常生活中的后果及其与情绪和行为障碍的关系仍有待阐明。
