Galioto Rachel, O'Leary Kevin C, Gunstad John, Thomas J Graham, Lipton Richard B, Pavlović Jelena M, Roth Julie, Rathier Lucille, Bond Dale S
a Department of Psychiatry and Human Behavior , Alpert Medical School of Brown University/Rhode Island Hospital , Providence , RI , USA.
b Department of Psychiatry and Human Behavior , Alpert Medical School of Brown University/The Miriam Hospital Weight Control and Diabetes Research Center , Providence , RI , USA.
Int J Neurosci. 2018 Jan;128(1):63-70. doi: 10.1080/00207454.2017.1366474. Epub 2017 Sep 1.
While migraine and obesity are related and both conditions are associated with reduced executive functioning, no study has examined whether obesity exacerbates executive dysfunction in migraine. This cross-sectional study examined whether overweight/obesity moderated associations of migraine severity and associated features with inhibitory control, one aspect of executive function.
Women (n = 124) aged 18-50 years old with overweight/obesity body mass index (BMI) = 35.1 ± 6.4 kg/m and migraine completed a 28-day smartphone-based headache diary assessing migraine headache severity (attack frequency, pain intensity) and frequency of associated features (aura, photophobia, phonophobia, nausea). They then completed computerized measures of inhibitory control during an interictal (headache-free) period.
Participants with higher migraine attack frequency performed worse on the Flanker test (accuracy and reaction time; p < .05). Migraine attack frequency and pain intensity interacted with BMI to predict slower Stroop and/or Flanker Reaction Time (RT; p < .05). More frequent photophobia, phonophobia and aura were independently related to slower RT on the Stroop and/or Flanker tests (p < .05), and BMI moderated the relationship between the occurrence of aura and Stroop RT (p = .03).
Associations of migraine severity and presence of associated features with inhibitory control varied by BMI in overweight/obese women with migraine. These findings warrant consideration of weight status in clarifying the role of migraine in executive functioning.
虽然偏头痛与肥胖相关，且这两种情况都与执行功能下降有关，但尚无研究探讨肥胖是否会加重偏头痛患者的执行功能障碍。这项横断面研究调查了超重/肥胖是否会调节偏头痛严重程度及相关特征与执行功能的一个方面——抑制控制之间的关联。
124名年龄在18至50岁之间、体重指数（BMI）为35.1±6.4kg/m²且患有偏头痛的超重/肥胖女性完成了一份基于智能手机的为期28天的头痛日记，评估偏头痛的严重程度（发作频率、疼痛强度）以及相关特征（先兆、畏光、畏声、恶心）的发生频率。然后，她们在发作间期（无头痛期）完成了抑制控制的计算机化测量。
偏头痛发作频率较高的参与者在侧翼测验（准确性和反应时间；p<.05）中的表现较差。偏头痛发作频率和疼痛强度与BMI相互作用，预测了在Stroop测验和/或侧翼测验中反应时间较慢（p<.05）。畏光、畏声和先兆出现频率越高，与在Stroop测验和/或侧翼测验中反应时间较慢独立相关（p<.05），且BMI调节了先兆出现与Stroop测验反应时间之间的关系（p = .03）。
在超重/肥胖的偏头痛女性中，偏头痛严重程度及相关特征与抑制控制之间的关联因BMI而异。这些发现值得在阐明偏头痛在执行功能中的作用时考虑体重状况。
