Doll Dietrich, Bosche Friederike D, Stauffer Verena K, Sinicina Inga, Hoffmann Sebastian, van der Zypen Dominic, Luedi Markus M
1 Department of Procto-Surgery, St. Marienhospital Vechta, Academic Teaching Hospital of the Medizinische Hochschule Hannover, Vechta, Germany 2 Department of Surgery, Luzerner Kantonsspital Sursee, Sursee, Switzerland 3 Institute of Forensic Medicine, Technical University Munich, Munich, Germany 4 Marien-Krankenhaus Bergisch Gladbach, Bergisch Gladbach, Germany 5 Swiss Federal Office of Social Insurance, Bern, Switzerland 6 Department of Anesthesiology and Pain Therapy, Bern University Hospital Inselspital, University of Bern, Bern, Switzerland 7 Department of Surgery, Medical School, University of the Witwatersrand, Johannesburg, Soweto, South Africa.
Dis Colon Rectum. 2017 Sep;60(9):979-986. doi: 10.1097/DCR.0000000000000795.
Pilonidal sinus disease is thought to be caused by intrusion of hair into healthy skin; loose hair in the intergluteal fold is thought to promote disease. However, compelling evidence to support these postulates is lacking; the cause of pilonidal sinus disease remains uncertain.
To determine whether particular properties of hair are associated with susceptibility to pilonidal sinus disease, we compared physical properties of hairs of patients with pilonidal sinus disease with hairs from control subjects who were matched for sex, BMI, and age.
This was an experimental study with establishment of a mechanical strength test for single hairs to quantify the maximum vertical force that a hair could exert, following tests of strength of occipital, lumbar, and intergluteal hair.
Hair from patients with pilonidal sinus disease and matched control subjects were harvested from patients of the St. Marienhospital Vechta Department of Procto-Surgery.
A total of 17 adult patients with pilonidal sinus disease and 217 control subjects were included.
ANOVA and intraclass and interclass variations of data gained from mechanical strength tests of occipital, lumbar, and intergluteal hair were included.
Vertical hair strength was significantly greater in patients with pilonidal sinus disease. Occipital hair exhibited 20% greater, glabella sacralis 1.1 times greater, and intergluteal hair 2 times greater strength in patients with pilonidal sinus disease than in matched control subjects (all p = 0.0001). In addition, patients with pilonidal sinus disease presented with significantly more hair at the glabella sacralis and in the intergluteal fold.
The study was limited by its relatively small number of patients from a specific cohort of European patients.
Occipital hair exhibited considerable vertical strength. Because occipital hair exerted the greatest force and cut hair fragments were found in the pilonidal nest in large quantities, these data suggest that pilonidal sinus disease is promoted by occipital hair. See Video Abstract at http://links.lww.com/DCR/A435.
藏毛窦疾病被认为是由毛发侵入健康皮肤所致；臀间沟内的松散毛发被认为会促使疾病发生。然而，缺乏支持这些假设的有力证据；藏毛窦疾病的病因仍不确定。
为了确定毛发的特定属性是否与藏毛窦疾病的易感性相关，我们比较了藏毛窦疾病患者的毛发与性别、体重指数和年龄相匹配的对照受试者毛发的物理属性。
这是一项实验研究，在对枕部、腰部和臀间毛发进行强度测试后，建立了单根毛发的机械强度测试，以量化毛发所能施加的最大垂直力。
藏毛窦疾病患者和匹配对照受试者的毛发取自维希塔圣玛丽医院结直肠外科的患者。
共纳入17例成年藏毛窦疾病患者和217例对照受试者。
纳入枕部、腰部和臀间毛发机械强度测试所得数据的方差分析以及组内和组间差异。
藏毛窦疾病患者的毛发垂直强度明显更大。与匹配的对照受试者相比，藏毛窦疾病患者的枕部毛发强度高20%，骶部眉间毛发强度高1.1倍，臀间毛发强度高2倍（所有p = 0.0001）。此外，藏毛窦疾病患者骶部眉间和臀间沟的毛发明显更多。
该研究受到其来自特定欧洲患者队列的患者数量相对较少的限制。
枕部毛发表现出相当大的垂直强度。由于枕部毛发施加的力最大，且在藏毛窝中发现大量剪断的毛发碎片，这些数据表明枕部毛发会促使藏毛窦疾病发生。见视频摘要：http://links.lww.com/DCR/A435 。
