Department of Procto-Surgery and Pilonidal Sinus Research Group, Germany, St Marienhospital Vechta, Academic Teaching Hospital of the Medical School Hannover, Vechta, Germany.
Department of Anesthesiology, Amsterdam University Medical Centers, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Sci Rep. 2021 Mar 18;11(1):6210. doi: 10.1038/s41598-021-85830-1.
Our understanding of pilonidal sinus disease (PSD) is based on a paper published 29 years ago by Karydakis. Since then, surgeons have been taught that hair more easily penetrates wet skin, leading to the assumption that sweating promotes PSD. This postulate, however, has never been proven. Thus we used pilocarpine iontophoresis to assess sweating in the glabella sacralis. 100 patients treated for PSD and 100 controls were matched for sex, age and body mass index (BMI). Pilocarpine iontophoresis was performed for 5 min, followed by 15 min of sweat collection. PSD patients sweated less than their matched pairs (18.4 ± 1.6 µl vs. 24.2 ± 2.1 µl, p = 0.03). Men sweated more than women (22.2 ± 1.2 µl vs. 15.0 ± 1.0 µl in non-PSD patients (p < 0.0001) and 20.0 ± 1.9 µl vs. 11.9 ± 2.0 µl in PSD patients (p = 0.051)). And regular exercisers sweated more than non-exercisers (29.1 ± 2.9 µl vs. 18.5 ± 1.6 µl, p = 0.0006 for men and 20.7 ± 2.3 µl vs. 11.4 ± 1.4 µl, p = 0.0005 for women). PSD patients sweat less than matched controls. Thus sweating may have a protective effect in PSD rather than being a risk factor.
我们对藏毛窦疾病（PSD）的理解基于 Karydakis 29 年前发表的一篇论文。从那时起，外科医生就一直认为毛发更容易穿透潮湿的皮肤，因此假设出汗会促进 PSD。然而，这一假设从未得到证实。因此，我们使用毛果芸香碱离子电渗疗法来评估骶骨眉间的出汗情况。100 例 PSD 患者和 100 例对照组患者按性别、年龄和体重指数（BMI）匹配。进行毛果芸香碱离子电渗治疗 5 分钟，然后收集 15 分钟的汗液。PSD 患者的出汗量少于他们的匹配组（18.4±1.6µl 对 24.2±2.1µl，p=0.03）。男性比女性出汗多（22.2±1.2µl 对非 PSD 患者的 15.0±1.0µl（p<0.0001）和 20.0±1.9µl 对 PSD 患者的 11.9±2.0µl（p=0.051））。有规律锻炼的人比不锻炼的人出汗多（29.1±2.9µl 对 18.5±1.6µl，男性 p=0.0006；20.7±2.3µl 对 11.4±1.4µl，女性 p=0.0005）。PSD 患者的出汗量少于匹配对照组。因此，出汗可能对 PSD 有保护作用，而不是危险因素。
