Fernström M, Uvnäs-Moberg K, Emås S
Dig Dis Sci. 1987 Feb;32(2):177-83. doi: 10.1007/BF01297106.
Meat in the stomach or duodenum potentiates pentagastrin-induced acid secretion in cats, presumably by a humoral mechanism. In the present study on cats, a meat meal significantly augmented the maximal acid response from a Heidenhain pouch (HP) to pentagastrin or to human synthetic gastrin I by 31 and 30%, respectively. The maximal HP acid response to pentagastrin was augmented also by peptone instilled into the stomach through a gastric fistula. Intravenous infusion of amino acids stimulated acid secretion but did not augment the maximal acid response to pentagastrin. The plasma concentrations of gastrin and somatostatin increased during infusion of pentagastrin and gastrin I and were not further altered by simultaneous feeding. The present results indicate that the mechanism for potentiation of gastrin-induced acid secretion is of physiological significance, since feeding augmented also the acid response to heptadecapeptide gastrin, the only gastrin secreted from the antrum and duodenum in cats. The potentiation of acid secretion is not dependent on the vagal excitation induced by oral feeding, since potentiation was demonstrated also by intragastric peptone instillation. The mechanism for the potentiation is not due to absorbed amino acids or a decrease of plasma somatostatin.
胃或十二指肠中的肉类可能通过体液机制增强猫体内五肽胃泌素诱导的胃酸分泌。在本项针对猫的研究中，一顿肉餐使海登海因小胃（HP）对五肽胃泌素或人合成胃泌素I的最大酸反应分别显著增强了31%和30%。通过胃瘘向胃内注入蛋白胨也增强了HP对五肽胃泌素的最大酸反应。静脉输注氨基酸刺激了胃酸分泌，但并未增强对五肽胃泌素的最大酸反应。在输注五肽胃泌素和胃泌素I期间，胃泌素和生长抑素的血浆浓度升高，同时进食并未使其进一步改变。目前的结果表明，胃泌素诱导的胃酸分泌增强机制具有生理意义，因为进食也增强了对十七肽胃泌素的酸反应，十七肽胃泌素是猫胃窦和十二指肠分泌的唯一胃泌素。胃酸分泌的增强不依赖于口服进食引起的迷走神经兴奋，因为通过胃内注入蛋白胨也证明了增强作用。增强机制并非由于吸收的氨基酸或血浆生长抑素的减少。
