Lucey M R, Wass J A, Fairclough P D, O'Hare M, Kwasowski P, Penman E, Webb J, Rees L H
Gut. 1984 Nov;25(11):1217-20. doi: 10.1136/gut.25.11.1217.
Food and insulin hypoglycaemia raise plasma concentrations of somatostatin. Both also stimulate gastric acid secretion but it is not clear whether gastric acid itself has any effect on somatostatin secretion. We, therefore, studied the effect on plasma concentrations of somatostatin of infusion of 0.1 N HC1 into the stomach and duodenum of healthy subjects. Plasma somatostatin did not rise with a small dose of HC1 given intragastrically (15 mmol) or intraduodenally (4 mmol). After an intraduodenal infusion of 60 mmol HC1 over 30 minutes, sufficient to reduce intraluminal pH to 2, plasma somatostatin rose moderately in five subjects from a mean value (+/- SEM) of 32 +/- 3 pg/ml to a peak at 10 minutes of 54 +/- 11 pg/ml. It is concluded that: (a) intragastric acid infusions do not release circulating somatostatin in man; and (b) that intraduodenal acidification albeit at grossly supraphysiological doses is a moderate stimulus of plasma somatostatin release. Therefore, gastric acid is unlikely to be a major factor mediating postprandial plasma somatostatin release in man.
食物和胰岛素所致低血糖会使血浆生长抑素浓度升高。二者还会刺激胃酸分泌，但胃酸本身是否对生长抑素分泌有任何影响尚不清楚。因此，我们研究了向健康受试者胃和十二指肠内输注0.1N盐酸对血浆生长抑素浓度的影响。胃内给予小剂量盐酸（15 mmol）或十二指肠内给予（4 mmol）时，血浆生长抑素未升高。在30分钟内十二指肠内输注60 mmol盐酸，足以使管腔内pH值降至2，5名受试者的血浆生长抑素从平均值（±标准误）32±3 pg/ml适度升高，在10分钟时达到峰值54±11 pg/ml。得出以下结论：（a）胃内输注酸不会在人体内释放循环生长抑素；（b）十二指肠内酸化尽管处于严重超生理剂量，但仍是血浆生长抑素释放的适度刺激因素。因此，胃酸不太可能是介导人体餐后血浆生长抑素释放的主要因素。
