Mengist Hylemariam Mihiretie, Zewdie Olifan, Belew Adugna, Dabsu Regea
Department of Medical Laboratory Sciences, College of Medical and Health Sciences, Wollega University, P.O. Box: 395, Nekemte, Ethiopia.
BMC Res Notes. 2017 Aug 10;10(1):388. doi: 10.1186/s13104-017-2725-3.
The main objective of this study was to determine the prevalence and drug susceptibility pattern of group B Streptococci (GBS) among pregnant women. The specific objectives include; (1) To determine the prevalence of GBS colonization among pregnant women (2) To determine the drug susceptibility pattern of GBS among pregnant women and (3) To identify associated risk factors with GBS colonization among pregnant women.
The median age of the participants was 24.5 years (range 16-38) and 86% participants were urban residents. The total prevalence of maternal GBS colonization from vaginal swab culture was 12.2% (22/180). The prevalence of GBS colonization rate was significantly higher in those pregnant women above 37 weeks of gestation [AOR, 95% CI 2.1 (1.2, 11.6), P = 0.03] and married ones [AOR, 95% CI 3.2 (1.8, 11.6), P < 0.021]. Twenty (91%) of GBS isolates were sensitive to vancomycin and the highest resistance was observed against penicillin G (77.3%). The prevalence of GBS colonization in this study was significantly high and differed by gestational age and marital status. None of the GBS isolates were resistant to vancomycin but higher resistance was shown against Penicillin G.
本研究的主要目的是确定孕妇中B族链球菌（GBS）的流行率和药敏模式。具体目标包括：（1）确定孕妇中GBS定植的流行率；（2）确定孕妇中GBS的药敏模式；（3）识别孕妇中与GBS定植相关的危险因素。
参与者的中位年龄为24.5岁（范围16 - 38岁），86%的参与者为城市居民。阴道拭子培养中孕产妇GBS定植的总流行率为12.2%（22/180）。孕周超过37周的孕妇[比值比（AOR），95%置信区间（CI）2.1（1.2，11.6），P = 0.03]和已婚孕妇[比值比（AOR），95%置信区间（CI）3.2（1.8，11.6），P < 0.021]中GBS定植率显著更高。20株（91%）GBS分离株对万古霉素敏感，对青霉素G的耐药性最高（77.3%）。本研究中GBS定植的流行率显著较高，且因孕周和婚姻状况而异。没有GBS分离株对万古霉素耐药，但对青霉素G显示出较高的耐药性。
