Mengist Abeba
Department of Medical Laboratory Science, College of Medical and Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
iScience. 2025 Jul 17;28(8):113140. doi: 10.1016/j.isci.2025.113140. eCollection 2025 Aug 15.
Group B (GBS) colonization during pregnancy poses significant public health risks, contributing to adverse outcomes like neonatal septicemia, meningitis, and pneumonia. Transmission from mother to newborn during delivery is common. In Jimma, Ethiopia, limited data exist on GBS prevalence, risk factors, and antimicrobial resistance among pregnant women, with no universal screening protocol to mitigate neonatal infections. This study assessed GBS prevalence, antimicrobial susceptibility, and associated risk factors among 200 pregnant women at Jimma University Hospital. Vaginal swabs collected at 35-37 weeks gestation were cultured and tested for GBS using standard methods. Results showed a colonization rate of 13% (26/200), higher in multigravida (17%) compared to primigravida (3.4%). Resistance rates to ampicillin, penicillin, clindamycin, and erythromycin were 30.8%, 23.1%, 19.2%, and 15.4%, respectively. The findings underscore the importance of routine screening and susceptibility testing to inform prophylactic strategies and curb neonatal infections.
孕期B族链球菌（GBS）定植会带来重大公共卫生风险，可导致新生儿败血症、脑膜炎和肺炎等不良后果。分娩期间从母亲传播给新生儿的情况很常见。在埃塞俄比亚的吉马，关于孕妇中GBS患病率、危险因素和抗菌药物耐药性的数据有限，且没有减轻新生儿感染的通用筛查方案。本研究评估了吉马大学医院200名孕妇中GBS的患病率、抗菌药物敏感性及相关危险因素。在妊娠35 - 37周时采集阴道拭子，采用标准方法进行GBS培养和检测。结果显示定植率为13%（26/200），经产妇（17%）高于初产妇（3.4%）。对氨苄西林、青霉素、克林霉素和红霉素的耐药率分别为30.8%、23.1%、19.2%和15.4%。这些发现强调了常规筛查和药敏试验对于指导预防策略及控制新生儿感染的重要性。
