Carmona Eva M, Limper Andrew H
Thoracic Diseases Research Unit, Division of Pulmonary Critical Care and Internal Medicine, Department of Medicine, Mayo Clinic, Mayo Foundation, 200, 1st Street Southwest, Rochester, MN 55905, USA.
Thoracic Diseases Research Unit, Division of Pulmonary Critical Care and Internal Medicine, Department of Medicine, Mayo Clinic, Mayo Foundation, 200, 1st Street Southwest, Rochester, MN 55905, USA.
Clin Chest Med. 2017 Sep;38(3):393-402. doi: 10.1016/j.ccm.2017.04.003. Epub 2017 May 31.
Invasive fungal diseases cause high morbidity and mortality in an immunocompromised host. Antifungals are the drugs of choice and can be divided into 4 main groups: polyenes, azoles, echinocandins, and pyrimidine analogues. Each class has its specific mechanism of action, spectrum of activity, and pharmacokinetic and side effects. It is important to understand the precise use of the established and new antifungal agents to successfully manage these complex infections in an already tenuous and frail host. This article discusses the main characteristics, clinical uses, and secondary effects of the main antifungals used in clinical practice.
侵袭性真菌病在免疫功能低下宿主中可导致高发病率和死亡率。抗真菌药物是治疗的首选药物，可分为4大类：多烯类、唑类、棘白菌素类和嘧啶类似物。每一类都有其特定的作用机制、活性谱以及药代动力学和副作用。了解已确立的和新型抗真菌药物的精确用法对于在本已脆弱的宿主中成功处理这些复杂感染很重要。本文讨论了临床实践中使用的主要抗真菌药物的主要特点、临床用途和副作用。
